July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Mechanism of Stem Cell Mediated Corneal Regeneration
Author Affiliations & Notes
  • James Funderburgh
    Ophthalmology, Univ of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   James Funderburgh, None
  • Footnotes
    Support   NH Grants EY016415, EY024642; Department of Defense W81XWH-14-1-0465, RPB Stein Innovation Award
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2004. doi:https://doi.org/
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      James Funderburgh; Mechanism of Stem Cell Mediated Corneal Regeneration. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2004. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Presentation Description : Mesenchymal stem cells from corneal stroma prevent scarring and induce regeneration of organized transparent stromal tissue in animal models and in human trials. Mesenchymal stem cells from umbilical chord, adipose tissue, and bone marrow all appear to posses a similar regenerative potential. The regenerative pathway in cornea is initiated by interaction between stem cells and immune cells. Stem cells control the number and type of immune cells infiltrating into the cornea and interactions between stem and immune cells induce a regenerative phenotype in stem cells that results in secretion of TGFB3. We will discuss properties of the regenerative phenotype of adult stem cells and the mechanism that induces this novel cellular condition.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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