July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
In vivo imaging in the assessment of limbal stem cell function
Author Affiliations & Notes
  • Sophie X. Deng
    Ophthalmology, Stein Eye Institute, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Sophie Deng, Chiesi Farmaceutici S.p.A. (C), UCLA (P)
  • Footnotes
    Support  an unrestricted grant from Research to Prevent blindness, NEI grants EY5P30EY000331 and R01EY021797, California Institute for Regenerative Medicine CLIN1-08686
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2007. doi:
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    • Get Citation

      Sophie X. Deng; In vivo imaging in the assessment of limbal stem cell function. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2007.

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      © ARVO (1962-2015); The Authors (2016-present)

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Presentation Description : Limbal stem cells (LSCs) maintain the normal homeostasis and wound healing of corneal epithelium. Limbal stem cell deficiency (LSCD) is a pathologic condition that results from an insufficient amount of LSCs. Methods to stage the severity of LSCD have been lacking. Using newly developed ocular imaging modalities, such as in vivo confocal laser scanning microscopy and anterior segment OCT, microstructural changes including subbasal nerve density, epithelial thickness and basal cell density in the central cornea and limbus have been found to correlate with the degree of LSCD and precede the clinical signs of LSCD. There are limitations of anterior segment OCT in imaging the limbus. Quantitative criteria for the staging of LSCD can be established using these quantifiable parameters.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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