July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Influence of glaucoma on corneal biomechanical properties measured with a dynamic Scheimpflug analyzer
Author Affiliations & Notes
  • yuichi yasukura
    Opthalmolgy, Yodogawa Christian Hospital, Osaka, Osaka, Japan
    Opthalmolgy, Osaka University, Suita, Osaka, Japan
  • Atsuya Miki
    Opthalmolgy, Osaka University, Suita, Osaka, Japan
  • Tomoko Asai
    Opthalmolgy, Osaka University, Suita, Osaka, Japan
  • Yasushi Ikuno
    Opthalmolgy, Osaka University, Suita, Osaka, Japan
  • Naoyuki Maeda
    Opthalmolgy, Osaka University, Suita, Osaka, Japan
  • Kohji Nishida
    Opthalmolgy, Osaka University, Suita, Osaka, Japan
  • Footnotes
    Commercial Relationships   yuichi yasukura, Santen (R); Atsuya Miki, Alcon (R), Ellex (R), Kowa (R), Novartis (R), Otsuka (R), PfizerJapan (R), R-Tech (R), Santen (R), Senju (R), Topcon (R); Tomoko Asai, None; Yasushi Ikuno, Bayer (R), Novartis (R), Tomey (F), Topcon (F); Naoyuki Maeda, Alcon (R), AMO (R), B+L (R), HOYA (R), Japanese Ministry of the Education, Culture, Sports, Science and Technology (F), Johnson & Johnson (R), Menicon (R), Otsuka (R), Pfizer (R), Santen (R), Senjyu (R), TOMEY (R), Topcon (F); Kohji Nishida, Abbott medical Optics Japan (R), AMO (R), HOYA (R), J&J (R), Japanese Society for the Promotion of Science (F), Menicon (R), Ministry of education, culture, sports, science and Technology, Japan (F), Ministry of Health, Labor, and Welfare, Japan (F), MSD (R), National Institute of Biomedical Innovation Japan (F), NEDO (new energy and industrial technology development organization (F), Otsuka Pharmaceutical (F), Pfizer (F), Santen (R), Senjyu (R), Takeda (R), Wacamoto (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2019. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      yuichi yasukura, Atsuya Miki, Tomoko Asai, Yasushi Ikuno, Naoyuki Maeda, Kohji Nishida; Influence of glaucoma on corneal biomechanical properties measured with a dynamic Scheimpflug analyzer. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2019.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To evaluate the relationship between ocular biomechanical parameters measured with a dynamic Scheimpflug analyzer and glaucoma, as well as other baseline factors such as axial length, intraocular pressure (IOP), age and central corneal thickness (CCT).

Methods : Fifty-one eyes of 51 consecutive subjects with glaucoma and 75 eyes of 75 heathy subjects who underwent measurement of biomechanical parameters with a dynamic Scheimpflug analyzer (Corvis ST) were retrospectively investigated. Twenty-nine of 36 biomechanical parameters were selected for analyses based on measurement reliability and clinical relevance. The biomechanical parameters were compared between eyes with and without glaucoma using student’s t-test. The parameters that showed nearly significant difference (P<0.1) were further evaluated with multivariable models adjusting for axial length, IOP, age and CCT.

Results : The presence or absence of glaucoma was significantly (P<0.05) correlated with 17 out of 29 biomechanical parameters in multivariable models. Glaucoma was positively correlated with delta arc length at outward applanation (A2), and deflection length, max inverse radius, integrated radius, and ratio of deformation amplitude at highest concavity (HC), and the maximum delta arc length. On the other hand, glaucoma negatively correlated with time at inward applanation, deflection area, deflection amplitude, and time at A2, radius at HC, and whole eye movement. These results consistently indicate larger deformability of the cornea in eyes with glaucoma. Many biomechanical parameters showed significant correlation with other baseline factors (15 parameters with IOP, 17 parameters with CCT, 17 parameters with age, and 10 parameters with axial length).

Conclusions : Glaucoma significantly correlated with corneal biomechanical parameters measured with a dynamic Scheimpflug analyzer. Eyes with glaucoma showed larger deformability than healthy eyes. These results suggest that the IOP measured by noncontact tonometer and Goldmann applanation tonometer were lower than the real IOP in glaucomatous eyes. Many parameters showed significant relationships with other factors, suggesting the importance of adjustment for possible confounding effects of these factors when evaluating the relationship between glaucoma and biomechanical parameters.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×