July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Prospective cohort study for corneal endothelial cell loss after Baerveldt glaucoma implantation
Author Affiliations & Notes
  • Kentaro Iwasaki
    Department of Ophthalmology, University of Fukui, Yoshida, Fukui, Japan
  • Shogo Arimura
    Department of Ophthalmology, University of Fukui, Yoshida, Fukui, Japan
  • Yuji Takihara
    Department of Ophthalmology, University of Fukui, Yoshida, Fukui, Japan
  • Yoshihiro Takamura
    Department of Ophthalmology, University of Fukui, Yoshida, Fukui, Japan
  • Masaru Inatani
    Department of Ophthalmology, University of Fukui, Yoshida, Fukui, Japan
  • Footnotes
    Commercial Relationships   Kentaro Iwasaki, None; Shogo Arimura, None; Yuji Takihara, None; Yoshihiro Takamura, None; Masaru Inatani, Abbott Medical Optics (F), Abbott Medical Optics (R)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2075. doi:
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      Kentaro Iwasaki, Shogo Arimura, Yuji Takihara, Yoshihiro Takamura, Masaru Inatani; Prospective cohort study for corneal endothelial cell loss after Baerveldt glaucoma implantation
      . Invest. Ophthalmol. Vis. Sci. 2018;59(9):2075.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the corneal endothelial cell loss after Baerveldt glaucoma implantation (BGI).

Methods : We prospectively evaluated changes of the endothelial cell density (ECD) in cornea for 59 patients (59 eyes) who underwent BGI. Tubes were inserted into the anterior chamber (ac) in 45 eyes and pars plana (pp) in 14 eyes. The primary outcome measure was the change of corneal ECD after BGI. The secondary outcome measures included relationships between corneal ECD and the parameters of tube OCT images (the tube-cornea distance, and the tube-cornea angle), etc.

Results : In the acBGI group, the corneal ECD at the tube insertion quadrant significantly decreased 8.6% at 3 months (P=0.049), 11.1% at 6 months (P=0.049) and 12.9% at 12 months (P=0.039). In the other corneal areas, the corneal ECD decreased significantly at 12 months only: center, 11.1% loss (P=0.021) and contralateral quadrant, 11.3% loss (P=0.019). In the ppBGI group, no significant loss of corneal ECD was found in any corneal areas at any follow-up visits after surgery. The tube-cornea angle was correlated negatively with the rate of corneal ECD loss at tube insertion quadrant; r=-0.42 (P=0.010).

Conclusions : acBGI causes corneal endothelial cell loss. Corneal endothelial cell loss starts at the tube insertion quadrant. The narrower tube-corneal angle results in severer loss of the corneal endothelial cells.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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