July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Relationship between visual function and changes in optic nerve head parameters in open angle glaucoma patients with diabetes mellitus
Author Affiliations & Notes
  • June Geng
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Thomas A Ciulla
    Retina Service, Midwest Eye Institute, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    Glaucoma Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Fondazione G.B.Bietti, Rome, Italy
    University Eye Clinic, Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Fondazione IRCCS, Policlinico San Matteo, Pavia, Italy
  • Aaditya Shah
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • David Camp
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • George Eckert
    Biostatistics, Indiana University, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   June Geng, None; Alon Harris, AdOM (C), AdOM (I), CIPLA (C), Nano Retina (I), Oxymap (I); Thomas Ciulla, Ophthotech (I), Spark (I), Spark (E); Alice Chandra Verticchio Vercellin, None; Aaditya Shah, None; David Camp, None; George Eckert, None; Brent Siesky, None
  • Footnotes
    Support  Research to Prevent Blindness, NY, NY and American Diabetes Association Grant 1-12-IN-20
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2094. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      June Geng, Alon Harris, Thomas A Ciulla, Alice Chandra Verticchio Vercellin, Aaditya Shah, David Camp, George Eckert, Brent A Siesky; Relationship between visual function and changes in optic nerve head parameters in open angle glaucoma patients with diabetes mellitus. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2094.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To examine the relationship between baseline visual function and changes in optic nerve head (ONH) morphology in open angle glaucoma (OAG) patients with and without diabetes mellitus (DM).

Methods : 85 patients with OAG (16 with DM, 69 without DM) were assessed for visual function by 24-2 Swedish interactive threshold algorithm visual field exam using the Humphrey visual field machine and for ONH morphology by optical coherence tomography (OCT) every 6 months for a 4-year period. Pearson correlations were used to test for associations between measurements, with p<0.05 considered statistically significant.

Results : In OAG patients baseline mean deviation (MD) was -3.71 (95% CI: -5.56, -1.85) and -3.34 (-4.35, -2.33), pattern standard deviation (PSD) was 4.29 (2.51, 6.06) and 3.96 (3.01, 4.92) and advanced glaucoma intervention study (AGIS) score was 1.87 (0.79, 3.60) and 1.40 (0.85, 2.10) in patients with and without DM, respectively. In OAG patients with DM, changes in disk area and rim area were positively and significantly correlated to baseline MD (disk area: r=0.60, p=0.0121; rim area: r=0.66, p=0.0039) and negatively and significantly correlated to baseline PSD (disk area: r=-0.64, p=0.0059; rim area: r=-0.74, p=0.0006) and AGIS score (disk area: r=-0.61, p=0.0098; rim area: r=-0.63, p=0.0079), leading to a significant difference compared to patients without DM (disk area: MD p=0.0055, PSD p=0.0086, AGIS score p=0.0023; rim area: MD p=0.0056, PSD p=0.0011, AGIS score p=0.0139).

Conclusions : In OAG patients with DM, baseline visual function may be indicative of changes in ONH morphology after 4 years.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×