July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
The relationship between microperimetric retinal sensitivity and ganglion cell complex thickness in patients with low tension glaucoma
Author Affiliations & Notes
  • Akanksha Prasad
    Doheny Eye Institute, Los angeles, California, United States
    Retina, Jules Stein Eye Institute, Los angeles, California, United States
  • Tudor Cosmin Tepelus
    Doheny Eye Institute, Los angeles, California, United States
  • Muneeswar Gupta Nittala
    Doheny Eye Institute, Los angeles, California, United States
  • Sheena Song
    Doheny Eye Institute, Los angeles, California, United States
  • Vikas Chopra
    Doheny Eye Institute, Los angeles, California, United States
  • Srinivas R. Sadda
    Doheny Eye Institute, Los angeles, California, United States
    Retina, Jules Stein Eye Institute, Los angeles, California, United States
  • Footnotes
    Commercial Relationships   Akanksha Prasad, None; Tudor Tepelus, None; Muneeswar Nittala, None; Sheena Song, None; Vikas Chopra, Allergan (F); Srinivas Sadda, Allergan (F), Allergan (C), Carl Zeiss Meditec (F), CenterVue (C), Genentech (C), Genentech (F), Heidelberg Engineering (C), Iconic (C), NightstarX (C), Novartis (C), Optos (F), Optos (C), Thrombogenics (C), Topcon (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2120. doi:
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      Akanksha Prasad, Tudor Cosmin Tepelus, Muneeswar Gupta Nittala, Sheena Song, Vikas Chopra, Srinivas R. Sadda; The relationship between microperimetric retinal sensitivity and ganglion cell complex thickness in patients with low tension glaucoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2120.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Purpose: To investigate the relationship between retinal sensitivity as determined by Macular Integrity Assessment (MAIA) microperimetry, and ganglion cell complex (GCC) thickness on optical coherence tomography (OCT), in patients with low tension glaucoma (LTG).

Methods : Methods: Subjects with a known diagnosis of LTG were recruited from the Doheny-UCLA glaucoma clinics in this IRB-approved prospective study. All subjects underwent Cirrus OCT imaging (512x128 macular cube) in both eyes and a GCC thickness map was automatically computed. MAIA microperimetry was performed in both eyes using a 10-2 protocol ( a 37-stimuli grid overlying the central 10°; Goldmann III stimulus with a duration of 200 ms; 4–2 threshold strategy; 1° diameter red circle fixation target for MAIA). Global (entire ETDRS grid) mean GCC thickness (microns) and GCC thickness in individual ETDRS subfields was correlated with MAIA threshold sensitivity (dB) from test spots in the corresponding fields using Pearson correlation analysis.

Results : Results: A total of 58 eyes from 29 LTG cases were included in our study with a mean age of 60.0345±10.24 years. Mean global GCC thickness was found to be 67.88±13.52 microns whereas mean GCC thickness in superior and inferior hemifields were found to be 69.35±15.52 microns and 64.44±14.19 microns respectively. Mean global retinal sensitivity measured by the MAIA microperimeter was 26.64±2.99 dB. Mean retinal sensitivity in superior and inferior fields was 27.59±3.24 dB and 24.65±5.35 dB respectively. Global MAIA measurement was found to co-relate with global GCC measurement(r=0.386). Superior hemiretina and inferior hemiretina MAIA also correlated with superior and inferior GCC studied on OCT (r=0.598, r=0.393)
All p values statistically significant <0.0001).

Conclusions : Conclusion: There is strong correlation between MAIA microperimetry-derived retinal sensitivity and GCC thickness, even within individual EDTRS subfields. Microperimetry-based assessments in glaucoma patients may facilitate more precise and localized structure-function correlation.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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