July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
RELATIONSHIP OF DIABETIC RETINOPATHY IN COGNITIVE AND FUNCTIONAL STATE IN PATIENTS WITH STROKE
Author Affiliations & Notes
  • Alejandra Sabina Ruiz Franco
    OPHTHALMOLOGY, UNAM, MEXICO, MEXICO CITY, Mexico
  • Footnotes
    Commercial Relationships   Alejandra Ruiz Franco, None
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    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2177. doi:
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      Alejandra Sabina Ruiz Franco; RELATIONSHIP OF DIABETIC RETINOPATHY IN COGNITIVE AND FUNCTIONAL STATE IN PATIENTS WITH STROKE. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2177.

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Abstract

Purpose : Diabetic retinopathy (RD) lesions may reflect similar processes of damage to cerebral microcirculation. Signs of retinopathy are associated with a higher incidence of cerebrovascular disease (CVD), independently of other risk factors.



HYPOTHESIS.
The presence and degree of severity of diabetic retinopathy is an indicator of macrovascular and microangiopathic cerebral vascular damage associated with greater cognitive deterioration and greater disability in patients with stroke


GENERAL PURPOSE
To determine the relationship between diabetic retinopathy and cognitive, functional status in patients with stroke

Methods : A comparative cross-sectional study was performed in patients with Atherosclerosis Cerebral Infarction (ICA) of large and small vessels, with less than 6 months of evolution, to which the presence and severity of RD was determined, according to the ETDRS scale, neuropsychological tests. ( CASI and EXIT 25) and functional evaluation (RankinM and Barthel) was performed.

Results : 81 patients were included . RD prevalence of 35.8%. .When comparing means in the scores of neuropsychological tests and functional scales, a statistically significant difference was found in the patients with retinopathy, in the CASI ( 69.4 vs 78.8 P=0.046*) test, with a lower score and in the EXIT 25 test with a higher mean ( 69.4 vs 78.8 P=0.046*) which suggests Cognitive impairment in these patients. The results in the means of the functional scales were also lower in Barthel (75.56 vs 81.5 P=0.76) and higher in Rankin (2.13 vs1.82 P=0.84), which suggests a greater disability at the time of the review, however, these differences were not statistically significant for this variable.

It is observed that the most affected cognitive domains in patients with diabetic retinopathy were: attention / orientation and memory

Conclusions : RD was associated with lower scores on cognitive assessments, but not on functional scales. The results, when categorized and adjusted for age and anatomical characteristics of the infarct, maintained an association between the overall cognitive deficit measured by these scales. In the multivariate model of covariates, small-vessel infarction was found for additional cognitive deficit . This suggests that the microvascular damage found in retinopathy may contribute to the worse cognitive outcome in these patients

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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