July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
INTRA-OCULAR PRESSURE EVOLUTION AFTER CATARACT SURGERY, PERCEPOLIS STUDY REPORT NUMBER 4. A RANDOMIZED CLINICAL TRIAL.
Author Affiliations & Notes
  • Florian BLOCH
    Ophthalmology, Metz-Thionville Regional Hospital Center, Metz, France
    Faculty of medicine, University of Lorraine, Nancy, France
  • Marie-Soline LUC
    Ophthalmology Department , CHR de Metz-Thionville, Mercy Hospital, Metz, France
    Faculty of medicine, University of Lorraine, Nancy, France
  • Mohamed Zaidi
    Ophthalmology Department , CHR de Metz-Thionville, Mercy Hospital, Metz, France
  • Jean-Charles Vermion
    Ophthalmology Department , CHR de Metz-Thionville, Mercy Hospital, Metz, France
    Faculty of medicine, University of Lorraine, Nancy, France
  • Christophe Goetz
    Clinical Research support Unit, Metz-Thionville Regional Hospital Center, Metz, France
  • Chloé DUBROUX
    Ophthalmology Department , CHR de Metz-Thionville, Mercy Hospital, Metz, France
    Faculty of medicine, University of Lorraine, Nancy, France
  • George Hayek
    Ophthalmology Department , CHR de Metz-Thionville, Mercy Hospital, Metz, France
    Faculty of medicine, University of Lorraine, Nancy, France
  • Jean-Marc Perone
    Ophthalmology Department , CHR de Metz-Thionville, Mercy Hospital, Metz, France
  • Footnotes
    Commercial Relationships   Florian BLOCH, None; Marie-Soline LUC, None; Mohamed Zaidi, None; Jean-Charles Vermion, None; Christophe Goetz, None; Chloé DUBROUX, None; George Hayek, None; Jean-Marc Perone, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2224. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Florian BLOCH, Marie-Soline LUC, Mohamed Zaidi, Jean-Charles Vermion, Christophe Goetz, Chloé DUBROUX, George Hayek, Jean-Marc Perone; INTRA-OCULAR PRESSURE EVOLUTION AFTER CATARACT SURGERY, PERCEPOLIS STUDY REPORT NUMBER 4. A RANDOMIZED CLINICAL TRIAL.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2224.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : The PERCEPOLIS trial is a prospective, controlled, randomized study that compares two surgical methods of cataract (Divide and conquer versus nucleus subluxation) in terms of post-op endothelial cells loss. In this study we are interested in the intra-ocular pressure (IOP).

Methods : 241 patients' eyes were analyzed, were included patients underwent cataract surgery with visual acuity less than 0.2 logMAR. IOP was measured pre-op and at 3 months post-op, all glaucomatous patients were excluded, and none received anti-glaucomatous treatment post-op. The primary study endpoint was the IOP variation between pre-op and at 3 months post-op. The secondary study endpoints were factors associated with pre-op and 3 months post-op IOP variation. Those factors included: Implant’s power lower or higher than to 21D, age, sex, surgical technique, pre-op IOP, the hardness of the nucleus and finally the EPT (effective phacoemulsification time).

Results : Patients with a pre-op IOP of 10-14mmHg decreased their post-op IOP by -1 mmHg (SD 2, P<0.001), those with an IOP of 15-19mmHg decreased by -2 mmHg (SD 2, P <0.001), those with an IOP of 20-24mmHg decreased by -4 mmHg (SD 2, P <0.001), and those with an IOP of 25-29mmHg decreased by -9 mmHg (SD 2, P <0.001). For implant power lower or higher than 21D, the evolution of the IOP at 3 months was similar: -2 mmHg (SD 3, P = 0.83). In multivariate analysis, postoperative IOP at 3 months was significantly lowered compared to pre-op (P <0.001). In older patients, post-op IOP seems to decrease more than in younger patients (P = 0.02), the same results were observed for men (-2.6 mmHg SD 2.8, P = 0.05) compared to women (-2.2 mmHg SD 2.9, P = 0.05).The surgical technique (P = 0.32), the hardness of the nucleus (P = 0.58) and the EPT (P = 0.46) don’t seem to have any influence on the variation of IOP at 3 months post-op.

Conclusions : We find that all patients decreased their post-op IOP at 3 months, and even more those who had a higher pre-op IOP. A long-term randomized study would be interesting to confirm the persistence of the lowered IOP and its impact on potential future glaucomatous patients.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×