July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Prevalence and Clinical Characteristics of Pachydrusen in Polypoidal Choroidal Vasculopathy: Multimodal image study
Author Affiliations & Notes
  • Junwon Lee
    Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Suk Ho Byeon
    Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Junwon Lee, None; Suk Ho Byeon, None
  • Footnotes
    Support  This research was supported by grants of the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (grant number: 2017R1A2B4011045).
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2402. doi:
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      Junwon Lee, Suk Ho Byeon; Prevalence and Clinical Characteristics of Pachydrusen in Polypoidal Choroidal Vasculopathy: Multimodal image study. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2402.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the prevalence of a newly defined drusen type, pachydrusen, soft drusen, and subretinal drusenoid deposits (SDDs) in eyes with polypoidal choroidal vasculopathy (PCV) and fellow eyes and the relationship between each drusen type and the choroidal thickness, vascular morphology, and hyperpermeability.

Methods : The 169 eyes of 90 patients with PCV were retrospectively reviewed. The prevalence of each drusen type was evaluated using color fundus photography and optical coherence tomography (OCT). The choroidal thickness and presence of pachyvessels on OCT and choroidal vascular hyperpermeability on indocyanine green angiography were compared among the drusen groups.

Results : Pachydrusen, soft drusen and SDD were found in 49.3, 12.3 and 6.9% in PCV eyes. The mean subfoveal choroidal thickness of the pachydrusen, soft drusen, and SDD groups was 403.1, 184.4, and 176.4 µm. The pachydrusen group showed significantly thicker choroid than the others. The choroidal hyperpermeability was noticed at 41.7, 0, and 0% and the pachyvessel was observed at 80.6, 44.4, and 40% in pachydrusen, soft drusen, and SDD groups, respectively.

Conclusions : In PCV patients, pachydrusen was prevalent and associated with thicker choroid. PCV with pachydrusen was highly associated with choroidal vascular hyperpremeability and pachyvessel morphology than other types of drusens.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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