Abstract
Purpose :
To investigate the changing tendency of circulating serum amyloid A（SAA）in acute anterior uveitis（AAU）associated with ankylosing spondylitis (AS).
Methods :
89 patients with AAU treated in ZheJiang Eye Hospital from October 2016 to August 2017 were retrospectively analyzed. The clinical data including the general information of patients, the onset of AAU, systematic disease such as AS and the result of human leukocyte antigen B27 (HLA-B27), TORCH, SAA levels were collected and measured with Mann-Whitney U test.
Results :
Acute-phase SAA level was significantly higher in AAU patients compared to controls. SAA in active AAU was significantly higher than that in inactive AAU with or without AS (P<0.01). In active AAU patients，SAA level was detected to become higher due to the existence of AS (P<0.001). SAA levels were identified to decrease rapidly following the change of AAU status in 17 patients who had experienced inflammation from active status to inactive status (P<0.01). In addition，SAA enhanced the specificity to 87.5% of active AAU patients with AS compared with the HLA-B27. When the receiver operator characteristic (ROC) curve was performed, area under the curve (AUC)of the SAA suggested that SAA had a relatively higher efficiency in AAU with or without AS. The cutoff value of SAA in active AAU contributed to the primary diagnosis of AS.
Conclusions :
This study demonstrates that SAA has a positive correlation with the activity of AAU and whether or not AS is associated，which may facilitate potential AS patients selection in AAU.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.