July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Lens and Cornea Regeneration Using Endogenous Stem Cells
Author Affiliations & Notes
  • Kang Zhang
    Ophthalmology, University Of California, San Diego, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Kang Zhang, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2609. doi:
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      Kang Zhang; Lens and Cornea Regeneration Using Endogenous Stem Cells. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2609.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : The repair and regeneration of tissues using endogenous stem cells represents an ultimate goal in regenerative medicine. We explored a new approach to the management of cataracts, the leading cause of blindness, through isolation of lens epithelial stem/progenitor cells (LECs) in mammals and show that Pax6 and Bmi1 are required for LEC renewal. We further designed a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts. Our method differs conceptually from current practice, as it preserves endogenous LECs and their natural environment maximally, and regenerates lenses with visual function. Our approach thus demonstrates a novel treatment strategy for cataracts and provides a new paradigm for tissue regeneration using endogenous stem cells.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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