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Lucia Lapenna, Antonio Acquaviva; In vivo imaging of Posterior Polymorphous Corneal Dystrophy using Confocal Microscopy. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2671. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To Evaluate the morphological and ultrastructural findings in posterior polymorphous corneal dystrophy (PPCD) as imaged with laser scanning in vivo confocal microscopy (IVCM).
IVCM images of 3 subjects with PPCD who had typical slit-lamp biomicroscopic findings of endothelial vesicular, band, and/or placoid lesions were evaluated.
4 eyes of three patients (aged 7 to 5 years; 2 males 1 female) with PPCD were included in this prospective study. Laser scanning IVCM revealed hyporeflective, round, vesicular lesions with diameters ranging between 20 and 150 µm in 3 subjects, combined vesicular and curvilinear hyperreflective band-like lesions in 3 subjects, and combined vesicular and placoid hyperreflective lesions in 1 subject at the level of Descemet membrane (DM). Additional findings included giant and nucleated endothelial cells, endothelial deposits, and guttae-like dark spots. The mean endothelial cell density was 1575.6 ± 477.2 cells per square millimeter (range, 990-2365 cells/mm). The mean central corneal thickness was 605.3 ± 27.12 μm (range, 522-652 μm).
Laser scanning IVCM is able to highlight the characteristic microstructural alterations at the level of endothelium and DM in the setting of PPCD and may have diagnostic utility in equivocal cases with borderline biomicroscopic findings.Laser scanning IVCM is able to highlight the characteristic microstructural alterations at the level of endothelium and DM in the setting of PPCD and may have diagnostic utility in equivocal cases with borderline biomicroscopic findings.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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