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Koji Namiguchi, Atsushi Shiraishi; Eyelid pressures in glaucoma patients under treatment with prostaglandin ophthalmic solutions. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2686.
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© ARVO (1962-2015); The Authors (2016-present)
The eyelid pressure was a pressure exerted on the eyeball from the eyelids. Prostaglandin-associated peri-orbitopathy (PAP) is a group of clinical findings found in the patients under treatment with prostaglandin ophthalmic solutions (PGs), including an absence of dermatochalasis, a deep crease in the upper eyelid, ptosis of the upper eyelid, decreased prominence of the inferior orbital fat pads, enophthalmos, orbital fat atrophy, flattening of the lower eyelid bags, inferior scleral show, tight orbits, and deepening of the upper eyelid sulcus. We investigated the relationship with eyelid pressure and PAP in glaucoma patients under treatment with PGs.
Thirty-three glaucoma patients under treatment with PGs (26 men and 7 women; mean age 68.1 ± 11.7 years) at Ehime University hospital between August 2015 and July 2016 (PG group), and age and gender matched 20 normal volunteers (16 men and 4 women; mean age 62.7 ± 10.6 years) (N group) were studied. The upper and lower eyelid pressures were measured with the Eye-Lid Tension Analysis System (ELTAS), and the intraocular pressures (IOP) were also measured. In the PG group, eyelid pressure was measured in the eye which had longer treatment history, and the right eye was measured in the N group.
The mean IOP (mmHg) of the PG group (16.9 ± 5.7) was higher than that of the N group (13.9 ± 3.0) (p<0.001). The mean upper eyelid pressure (mmHg) was not different between the PG group (30.7 ± 6.9) and the N group (31.4 ± 6.7) (p=0.815), however the mean lower eyelid pressure (mmHg) was higher in the PG group (35.1 ± 8.0) than the N group (30.3 ± 6.6) (p=0.006). When the PG group was divided into PAP(+) group and PAP(-) group, the mean upper and lower lid pressure of PAP(+) group were 34.6 ± 9.3, and 39.2 ± 8.6 respectively and were significantly higher than those of PAP(-) group (29.2 ± 6.0, and 32.7 ± 6.1) (p=0.038, and p=0.002).
The results demonstrated that eyelid pressures in PAP(+) glaucoma patients were higher than those of PAP(-) patients, suggesting that PAP might be involved in the development or pathogenesis of glaucoma.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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