July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Effect of glaucoma surgery on post-injection IOP elevation in patients undergoing intravitreal anti-VEGF injections
Author Affiliations & Notes
  • Jocelyn Lam
    University of Washington, Seattle, Washington, United States
  • Ian Luttrell
    University of Washington, Seattle, Washington, United States
  • Kasra Rezaei
    University of Washington, Seattle, Washington, United States
  • Jennifer R Chao
    University of Washington, Seattle, Washington, United States
  • Yewlin Chee
    University of Washington, Seattle, Washington, United States
  • Leona Ding
    University of Washington, Seattle, Washington, United States
  • Joanne C Wen
    University of Washington, Seattle, Washington, United States
  • Footnotes
    Commercial Relationships   Jocelyn Lam, None; Ian Luttrell, None; Kasra Rezaei, None; Jennifer Chao, None; Yewlin Chee, None; Leona Ding, None; Joanne Wen, None
  • Footnotes
    Support  Research to Prevent Blindness
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2689. doi:
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      Jocelyn Lam, Ian Luttrell, Kasra Rezaei, Jennifer R Chao, Yewlin Chee, Leona Ding, Joanne C Wen; Effect of glaucoma surgery on post-injection IOP elevation in patients undergoing intravitreal anti-VEGF injections. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2689.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To characterize how incisional glaucoma surgery affects the intraocular pressure (IOP) elevation following intravitreal anti-VEGF injections.

Methods : Patients receiving intravitreal anti-VEGF injections with a history of incisional glaucoma surgery (trabeculectomy or glaucoma drainage device) were recruited. Control eyes that did not have a history of incisional glaucoma surgery were also recruited. Pre and post-injection IOP values were measured at 1-5 minute intervals following intravitreal injection. Pre and post-injection IOP values were compared among control and glaucoma surgery eyes.

Results : Four eyes with a history of glaucoma surgery and 23 control eyes were recruited. Mean age of patients with glaucoma surgery eyes was 70.2 ± 17.7 years and control eyes was 64.1 ± 12.4 years (p=0.2). In the glaucoma surgery eyes, the most common indication for intravitreal anti-VEGF injection was vein occlusion (50%) while diabetic macular edema was the most common indication for control eyes (53%). Indications for glaucoma surgery included primary open angle glaucoma (3/4) and neovascular glaucoma (1/4). Post-injection IOP was significantly increased compared to baseline IOP after anti-VEGF injection in control eyes (mean change in IOP = 28.2 ± 9.6 mmHg; p<0.001) and in glaucoma surgery eyes (mean change in IOP = 13.1 ± 6.7 mmHg; p=0.03). The mean change in IOP following intravitreal anti-VEGF injection in glaucoma surgery eyes was significantly less than in control eyes (p=0.006, unpaired t-test). The mean time for the IOP to return to within 10 mmHg of pre-injection IOP was less in glaucoma surgery eyes (6.1 ± 5.4 mins) than in control eyes (13.4 ± 8.2 mins) but did not reach statistical significance (p=0.09).

Conclusions : Although intravitreal anti-VEGF injections lead to a significant rise in IOP in eyes with or without glaucoma surgery, glaucoma surgery eyes had significantly less post-injection IOP elevation compared to control eyes.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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