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Mukharram Bikbov, Rinat Fayzrakhmanov, Venera Salavatova, Gyulli Kazakbaeva, Jost B Jonas; Intraocular pressure and its associations in a Russian population: The Ural Eye and Medical Study. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2722.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the normal distribution of the intraocular pressure (IOP) and its associations in a Russian population.
The population-based Ural Eye and Medical Study was conducted in a rural and an urban area in the region of Ufa / Bashkortostan 1400 km East of Moscow. Out of 7328 eligible individuals aged 40+ years, the study included 5,899 (80.5%) participants who underwent an ocular and general examination. IOP was measured by non-contact tonometry.
Mean IOP was 13.51 ± 0.3.89 mmHg (median: 12 mm Hg; range: 1-49 mmHg). It decreased significantly (P<0.001) to 13.14 ± 3.96 mmHg after medical mydriasis. The 95% confidence interval (CI) ranged from 8 mmHg to 23mmHg. In multivariate analysis higher IOP was associated (regression coefficient r: 0.35) with thicker central corneal thickness (P<0.001; standardized regression coefficient beta: 0.31; non-standardized regression coefficient B: 0.04; 95%CI: 0.03,0.04), longer axial length (P<0.001;beta:0.08;B:0.29;95%CI:0.17,0.42), higher systolic blood pressure (P<0.001;beta:0.10;B:0.02;95%CI:0.01,0.03), higher body mass index (P=0.001;beta:0.06;B:0.05;95%CI:0.02,0.08), and female gender (P<0.001;beta:0.10;B:0.75;95%CI:0.49,1.02). In that model, IOP was not significantly associated with age (P=0.23) and ankle-brachial index (P=0.18).
The 95% CI of the IOP distribution in a Russian population ranged from 8mmHg to 23mmHg with a mean and median of 13.5mmHg and 12mmHg, respectively. IOP depended on central corneal thickness, gender, axial length, systolic blood pressure and body mass index. Future studies may address, whether taking into account the dependencies of IOP on these parameters may lead to a more personalized definition of the normal IOP range.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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