July 2018
Volume 59, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2018
Pseudoexfoliation and its associations in a Russian population: The Ural Eye and Medical Study.
Author Affiliations & Notes
  • Dilya Yakupova
    Ufa Eye Research Institute, Ufa, Russian Federation
  • Mukharram Bikbov
    Ufa Eye Research Institute, Ufa, Russian Federation
  • Rinat Fayzrakhmanov
    Ufa Eye Research Institute, Ufa, Russian Federation
  • Timur Gilmanshin
    Ufa Eye Research Institute, Ufa, Russian Federation
  • Guzel Bikbova
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan
  • Jost B Jonas
    Department of Ophthalmology, Medical Faculty Mannheim, Mannheim, Germany
  • Footnotes
    Commercial Relationships   Dilya Yakupova, None; Mukharram Bikbov, None; Rinat Fayzrakhmanov, None; Timur Gilmanshin, None; Guzel Bikbova, None; Jost Jonas, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2723. doi:https://doi.org/
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      Dilya Yakupova, Mukharram Bikbov, Rinat Fayzrakhmanov, Timur Gilmanshin, Guzel Bikbova, Jost B Jonas; Pseudoexfoliation and its associations in a Russian population: The Ural Eye and Medical Study.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2723. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess prevalence and associations of pseudoexfoliation in a Russian population.

Methods : The population-based Ural Eye and Medical Study was carried out in a rural and an urban area in the region of Ufa / Bashkortostan 1400 km East of Moscow. Out of 7328 eligible individuals aged 40+ years, 5,899 (80.5%) individuals participated and underwent an ocular and general examination. After medical dilation of the pupil, the presence of pseudoexfoliation was determined by slit-lamp based biomicroscopy.

Results : Examination data were available for 5779 (98.0%) individuals, while 39 eyes were pseudophakic or aphakic and 81 eyes could not be examined for pseudoexfoliation. Mean prevalence of pseudoexfoliation was 204/5779 or 3.53% (95% confidence interval (CI): 3.05,4.01). It increased from 0.2% (95%CI:0.00,0.06) in the age group of 40-44 years, to 1.5% (95%CI:0.7,2.3) (age: 50-54 years), 6.1% (95%CI:4.4,7.8) (age: 65-69 years) and to 8.0% (95%CI: 5.3,10.7) in the age group of 75+ years. In multivariate analysis, higher prevalence of pseudoexfoliation was associated with older age (P<0.001; odds ratio (OR): 1.07;95%CI:1.06,1.09), Russian ethnicity (versus Tartars, Bashkirks and others) (P=0.03;OR:1.41;95%CI:1.03,1.92) and higher intraocular pressure (P<0.001;OR:1.09;95%CI:1.06,1.12), while it was not significantly associated with gender (P=0.68), systolic (P=0.58) or diastolic (P=0.39) blood pressure, prevalence of diabetes mellitus (P=0.31), axial length (P=0.11), or lens thickness (P=0.23).

Conclusions : The prevalence of pseudoexfoliation in this population from Russia with an age of 40+ years was 3.5%. It strongly increased with older age and was more common in Russians than non-Russian. It was not significantly associated with axial length, diabetes mellitus and blood pressure.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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