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Akiko Miki, Mayuka Hayashida, Yukako Inoue, Yuko Yamada, Makoto Nakamura; The relationship between foveal avascular zone and fixation stability in patients with a history of retinopathy of prematurity.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2753.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the relationship between foveal avascular zone (FAZ) and fixation stability in the eyes with a history of retinopathy of prematurity (ROP) in comparison to the control eyes.
OCT angiography was performed using Cirrus AngioPlex (Zeiss) in patients with a history of ROP (ROP group, 18 eyes of 10 patients; age range, 7–12 years) and in age-matched control subjects (Control group, 20 eyes of 18 patients; age range, 7–12 years). A scan area of 3 × 3 mm was selected in the superficial retinal layers. FAZ was manually measured using ImageJ software. Fixation stability was assessed with the Nidek microperimeter-3 (MP-3). The quantitative measure of fixation stability was calculated with a bivariate contour ellipse area (BCEA). Statistical analysis was performed using the generalized estimating equations method.
The FAZ area was significantly smaller in the ROP group (0.24 ± 0.18 mm2) than in the control group (0.39 ± 0.07 mm2) (p=0.001). The BCEA was 1.67±0.82 deg2 in the ROP group and 1.51±0.82 deg2 in the control group. There was no significant differences between two groups (p=0.53). Multivariate analysis showed that the BCEA was significantly associated with visual acuity (p < 0.001), but not with the FAZ area (p=0.53).
Eyes with a history of ROP have a small FAZ area. The small FAZ may not affect the fixation stability in ROP patients.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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