July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Influence of serial retinal images on the diagnosis and management of retinopathy of prematurity (ROP)
Author Affiliations & Notes
  • Shin Hae Park
    Department of Ophthalmology, University of Illinois at Chicago, Chicago, Illinois, United States
    Department of Ophthalmology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea (the Republic of)
  • Kai Kang
    Department of Ophthalmology, University of Illinois at Chicago, Chicago, Illinois, United States
  • Sang Jin Kim
    Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
    Samsung Medical Center, Sungkyunkwan University, Seoul, Korea (the Republic of)
  • Karyn Jonas
    Department of Ophthalmology, University of Illinois at Chicago, Chicago, Illinois, United States
  • Susan Ostmo
    Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • J. Peter Campbell
    Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Michael F Chiang
    Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Robison Vernon Paul Chan
    Department of Ophthalmology, University of Illinois at Chicago, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Shin Hae Park, None; Kai Kang, None; Sang Jin Kim, None; Karyn Jonas, None; Susan Ostmo, None; J. Peter Campbell, None; Michael Chiang, Clarity Medical Systems (Pleasanton, CA) (S), Novartis(Basel, Switzerland) (C); Robison Chan, Visunex Medical Systems (Fremont, CA) (C)
  • Footnotes
    Support  R01 EY019474 from the National Institutes of Health (Bethesda, Maryland), P30 EY010572 from the National Institutes of Health (Bethesda, Maryland), NSF SCH-1622679, P30 EY001792 Core Grant for Vision Research from the National Institutes of Health (Bethesda, Maryland), RPB departmental grant (Unrestricted Grant from Research to Prevent Blindness)
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2761. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Shin Hae Park, Kai Kang, Sang Jin Kim, Karyn Jonas, Susan Ostmo, J. Peter Campbell, Michael F Chiang, Robison Vernon Paul Chan; Influence of serial retinal images on the diagnosis and management of retinopathy of prematurity (ROP). Invest. Ophthalmol. Vis. Sci. 2018;59(9):2761.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Wide-angle digital retinal imaging is currently being utilized for retinopathy of prematurity (ROP) telemedicine programs. Digital imaging has allowed serial comparison of vascular change over time, which anecdotally many clinicians describe as being informative. This study examines the influence of serial retinal images on ROP diagnosis and management.

Methods : Seven ROP examiners interpreted 30 sets (15 images of single image and 15 images of serial images) from 15 eyes with ROP. Images were independently reviewed on a secure website and a three-level plus disease diagnosis and management plan (follow-up interval or treatment) for each index case were recorded, first based on a single retinal photograph, and then based on a series of three images over time with the index image as the third image. Changes in diagnosis and management in ROP using single and serial images were determined. Intra and inter-grader reliability was calculated using the kappa statistics.

Results : When viewing the serial retinal images, graders changed their diagnosis in 24 (22.9%) and management in 32 (30.5%) of total 105 image pairs. Of the 24 changes in determining plus disease after viewing serial images, 18 responses (75.0%) were changes toward more severe and 6 responses (25.0%) were toward less severe disease. Intra-grader agreement between single and serial image assessment was variable (Cohen’s kappa ranged from 0.17 to 1.0). Inter-grader agreement was moderate for single image analysis (Fleiss’ kappa=0.48, 95% CI 0.40-0.57) and fair for serial image analysis (Fleiss' kappa=0.31, 95% CI 0.23-0.39)

Conclusions : Analyzing a progression of serial retinal images enables direct comparison of vascular changes over time in ROP. The findings in this study suggest a potential effect of using serial images to diagnose plus disease, as opposed to using a single image at a single point in time. The implication of this change requires further study. More objective and quantitative techniques may assist in providing a more consistent and precise identification of retinal vascular progression.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×