July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Symmetry of Disease in Retinopathy of Prematurity
Author Affiliations & Notes
  • Alyssa Spiller
    Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
  • Anne Jensen
    Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
  • Gui-Shuang Ying
    Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • Graham E Quinn
    Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
  • Lauren Tomlinson
    Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
  • Gil Binenbaum
    Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
    Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2774. doi:
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    • Get Citation

      Alyssa Spiller, Anne Jensen, Gui-Shuang Ying, Graham E Quinn, Lauren Tomlinson, Gil Binenbaum; Symmetry of Disease in Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2774.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Correlation of retinopathy of prematurity (ROP) between eyes has been reported in high-risk populations. We sought to evaluate inter-eye symmetry for ROP in a broad-risk cohort representative of infants undergoing ROP screening.

Methods : Retrospective cohort study of infants undergoing ROP examinations from 29 hospitals between 2006-2012 (The G-ROP Study). Primary outcomes were symmetry for type (type 1, 2, not 1 or 2, no ROP), highest stage of ROP, and disease course of asymmetric fellow eyes when one eye developed type 1.

Results : 7483 infants were studied. 94% of right and left eyes were symmetric for type. 93% of eyes were symmetric for highest stage. 378/459 (82%) infants developed type 1 in both eyes together. In 44 infants, one eye had type 1 and the fellow eye was treated simultaneously for type 2. All 37 remaining fellow eyes had ROP: 8 developed type 1 and were treated (6 within 2 weeks, all within 4 weeks); 4 developed type 2 and regressed; and 25 developed ROP less than type 1 or 2 and regressed.

Conclusions : ROP is a highly symmetric disease between eyes with respect to the presence and severity of disease. When type 1 ROP develops in only one eye, the risk of progression to type 1 in the fellow eye is very low if it has not occurred within 4 weeks.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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