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Cheolmin Yun, Boram Lee, Seong-Woo Kim, Jaeryung Oh; Choriocapillaris flow features and choroidal vasculature in fellow eyes of patients with central serous chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2812.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate characteristics of the choriocapillaris flow based on the underlying choroidal vasculature in fellow eyes with central serous chorioretinopathy (CSC).
In this retrospective study, we included CSC patients and age and sex matched normal controls. Patients underwent swept-source (SS) optical coherence tomography (OCT) angiography in order to evaluate the choroidal vascular flow area of choriocapillaris. We defined a choroid just below the choriocapillaris layer as choroidal bed and divide it into two compartments, vascular and stromal bed according to the existence of choroid vessels using an en-face OCT image. With an OCT angiography image and its vascular density map, flow void area was defined. Flow void areas were compared between CSC and control group and its characteristics were investigated according to the underlying choroidal bed. The mean macular choroidal thickness (CT) of the seven points within a 3mm-zone macula.
Fifty-seven fellow eyes of CSC patients and normal controls were included. The mean macular CT of CSC fellow eyes (335.26 ± 54.18 µm) was greater than that of normal controls (272.77 ± 36.82 µm, P < 0.001). Flow void area was found in 34 eyes (59.6%) in CSC fellow eyes and 17 (29.8%) eyes in controls (P = 0.002). In CSC fellow eyes, the mean flow void area and ratio of choriocapillaris over vascular bed (0.051 ± 0.056 mm2 and 1.07 ± 1.18 %) were greater than those over stromal bed (0.018 ± 0.019 mm2 and 0.42 ± 0.45 %) (P < 0.001). The presence of flow void area in CSC group was associated with greater mean macular CT (P = 0.004).
CSC fellow eyes showed more flow-void area on choriocapillaris than normal controls. The location of flow void area was associated with the distribution of underlying choroidal vessels. The underlying choroidal vessels may affect the choriocapillaris perfusion in pachychoroid eyes.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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