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Humberto Ruiz-Garcia, Mariana Ingolotti, Perla Monserrat Madrigal-Ruiz, Raul Lopez-Cervantes, Enrique Roig-Melogranados; Quantitative OCT-A analysis in patients treated with anti-VEGF therapy for macular edema.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2816. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To describe and analyze optical coherence tomography angiography (OCT-A) quantitative changes pre and post anti-VEGF therapy in patients treated for macular edema.
Retrospective case series performed in a private practice setting in Mexico. Records of previously anti-VEGF (Bevacizumab, Ranibizumab) treated patients for macular edema due to diabetes or central/branch retinal vein occlusion who required additional injections were considered. Only OCT-A exams with signal strength above 7 were selected. Collected data included: demographics, measurements of Central Perfusion (CP) and Central Vessel (CV) using Cirrus Angioplex Metrix TM Software (Carl Zeiss Meditec, Dublin, CA), central macular thickness (CMT) using SD-OCT (Carl Zeiss Meditec, Dublin, CA), automated and manual foveal avascular zone assessment (FAZ).
Thirty-two patients between March and September 2017 with complete data were included in this study. Average age was 63 ± 15 years. Average number of previously received injections was 6.13 ± 5.5. Mean CMT pre-treatment was 316±139 µm and CMT post-treatment was 267±82 µm (p=0.108). No significant changes in quantitative measurements were observed between pre (CP 0.15 ± 0.98 and CV 6.62 ± 4.30) and 1-month (CP 0.13 ± 0.10 and CV 6.03 ± 4.01) post-injected responder patients. Nevertheless, statistically significant positive correlation was found between central perfusion and central vessel measurements (R=0.944 p=0.001). Furthermore, central vessel measurements had a negative correlation with manually executed FAZ (R=-0.387 p= 0.029) and a positive correlation with SD-OCT central macular thickness (R= 0.404 p=0.022). Finally, mean pre and post injection signal strength (8.2±1.2; 8.03±1.5, respectively) correlated positively with both vessel (R= 0.471 p=0.007) and perfusion data (R=0.550 p=0.001). Podes agregar promedio de espesor macular pre y post ?
There does not seem to be a significant change in central vessel and perfusion findings one month after anti-VEGF intravitreal injection in patients with macular edema. Data suggests that vessel and perfusion variables are strongly correlated. Agregar alguna conclusion acerca de la herramienta ? poner lo que pensamos que pasa con la correlacion postiva con el OCT ?Sugerimos que se deberia realizar el mismo trabajo en naive ??
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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