July 2018
Volume 59, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2018
Cross-sectional association between OCT angiography-measured optic nerve head and macular vessel densities and age in healthy eyes
Author Affiliations & Notes
  • Khoa Dinh Nguyen
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
    Northeast Ohio Medical University, Rootstown, Ohio, United States
  • Patricia Isabel C Manalastas
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
  • Christopher Bowd
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
  • Kyle Hasenstab
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
  • Andrew J Li
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
    Dartmouth College, Hanover, New Hampshire, United States
  • Rafaella Penteado
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
  • Huiyuan Hou
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
  • Takuhei Shoji
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
  • George Villatoro
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
    UCSD School of Medicine, University of California, San Diego, La Jolla, California, United States
  • Elham Ghahari
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
  • Sasan Moghimi
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
  • Robert N Weinreb
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
  • Linda M Zangwill
    Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Khoa Nguyen, None; Patricia Isabel Manalastas, None; Christopher Bowd, None; Kyle Hasenstab, None; Andrew Li, None; Rafaella Penteado, None; Huiyuan Hou, None; Takuhei Shoji, Alcon (R), Kowa (R), Otsuka (R), Pfizer (R), Santen (R), Senju (R); George Villatoro, None; Elham Ghahari, None; Sasan Moghimi, None; Robert Weinreb, Aerie Pharmaceuticals (C), Alcon (C), Allergan (C), Bausch & Lomb (C), Carl Zeiss Meditec Inc. (F), CenterVue Inc. (F), Eyenovia (C), Genentech Inc. (F), Heidelberg Engineering GmbH (F), Konan Medical USA Inc. (F), Novartis (C), Optos Inc. (F), Optovue Inc. (F), Sensimed AG (C), Topcon Medical Systems Inc. (F), Unity (C), Valeant (C); Linda Zangwill, Carl Zeiss Meditec Inc. (F), Heidelberg Engineering GmbH (F), National Eye Institute (F), Optovue Inc. (F), Topcon Medical Systems Inc. (F)
  • Footnotes
    Support  NIA T35AG26757, Stein Institute for Research on Aging and the Center for Healthy Aging at UC San Diego (KN); NEI R01EY022039, R21EY027945 (CB); NEI P30EY022589 (KH); UC San Diego Clinical and Translational Research Institute 1TL1TR001443 (GAV); NEI R01EY023704 (RNW); NEI R01EY011008, R01EY026590, R01EY027510, P30EY022589 (LMZ) and participant retention incentive grants in the form of glaucoma medication at no cost from Alcon Laboratories Inc., Allergan, Alcon, Pfizer Inc., and Santen Inc. Unrestricted grant from Research to Prevent Blindness, New York, New York
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2861. doi:
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    • Get Citation

      Khoa Dinh Nguyen, Patricia Isabel C Manalastas, Christopher Bowd, Kyle Hasenstab, Andrew J Li, Rafaella Penteado, Huiyuan Hou, Takuhei Shoji, George Villatoro, Elham Ghahari, Sasan Moghimi, Robert N Weinreb, Linda M Zangwill; Cross-sectional association between OCT angiography-measured optic nerve head and macular vessel densities and age in healthy eyes. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2861.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the association between age and vessel density measurements of the optic nerve head and macula in healthy eyes using Angiovue Optical Coherence Tomography Angiography (OCTA).

Methods : One-hundred-seven eyes of 57 healthy participants (mean age = 60.3 years, range = 32 to 89 years) enrolled in Diagnostic Innovations in Glaucoma Study (DIGS) with good quality OCTA images were examined. Ocular microvasculature was summarized as superficial vessel density, defined as the percentage area occupied by blood vessels within a bounded area. Four vessel density measurements were utilized: (1) ONH whole image vessel density (ONH wiVD) measured as a 4.5 x 4.5mm scan field over the optic disc; (2) circumpapillary vessel density (cpVD) measured as a 750 μm wide elliptical annulus extended around the optic disc; (3) macular whole image vessel density (mwiVD) measured as a 3 x 3 mm scan field over the macula; and (4) parafoveal vessel density (pfVD) measured as a 150 μm wide elliptical annulus centered on the macula. Linear and quadratic associations between age and vessel density measurements were assessed using linear mixed effects models with a random intercept.

Results : For each year of age there was a mean (95%CI) reduction of ONH wiVD, cpVD, mwiVD and pfVD of -0.09% (-0.13 to 0.05, p < 0.001), -0.09% (-0.13 to -0.04, p = 0.001), -0.12% (-0.18 to -0.06, p = 0.001) and -0.10% (-0.16 to -0.04, p = 0.003), respectively, using the linear age model. Age explained between 27% and 43% of the variability in vessel density. Specifically, negative associations between age and vessel density measurements for all images of the ONH and macula were statistically significant (ONH wiVD: r2 = 0.43; cpVD, r2 = 0.35; mwiVD, r2 = 0.32; pfVD, r2 = 0.27; p < 0.05 for all linear associations). For ONH wiVD, mwiVD, and pfVD, vessel density decreased with age at an increasing rate (ONH wiVD, r2 = 0.48; mwiVD, r2 = 0.37; pfVD, r2 = 0.33; p < 0.05 for all quadratic associations).

Conclusions : Vessel density of the ONH and macula decreases with increasing age when assessed cross-sectionally. In some cases, at older ages, vessel density decreases at an increasing rate. Age-related loss of microvasculature should be considered when using OCTA measurements for clinical management of ocular diseases.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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