July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Comparison of Optic Nerve Head and Peripapillary Vascular Density and Flow Area Between Healthy Black and White Subjects Using Optical Coherence Tomography Angiography
Author Affiliations & Notes
  • Megan Silas
    Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States
  • Lindsay Chun
    University of Chicago Pritzker School of Medicine, Chicago, Illinois, United States
  • Liliya Golas
    Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States
  • J. Erik Kulenkamp
    University of Chicago Pritzker School of Medicine, Chicago, Illinois, United States
  • Dimitra Skondra
    Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States
    J. Terry Ernest Ocular Imaging Center, University of Chicago, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Megan Silas, None; Lindsay Chun, None; Liliya Golas, None; J. Erik Kulenkamp, None; Dimitra Skondra, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2874. doi:
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      Megan Silas, Lindsay Chun, Liliya Golas, J. Erik Kulenkamp, Dimitra Skondra; Comparison of Optic Nerve Head and Peripapillary Vascular Density and Flow Area Between Healthy Black and White Subjects Using Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2874.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : It is well recognized that black populations have an increased prevalence of glaucoma when compared to white populations, although the etiology of this predisposition is unknown. The purpose of this study is to investigate the differences in the vascular properties of the optic nerve head (ONH) and peripapillary area using optical coherence tomography angiography (OCTA) of healthy black and white subjects to better understand whether vascularity plays a role in this predisposition.

Methods : Thirty-four eyes of 17 young healthy black subjects and 50 eyes of 25 young healthy white subjects underwent OCTA imaging using RTVue XR Avanti (Optovue, Freemont, CA, USA). ONH properties and retinal nerve fiber layer (RFNL) thickness were calculated using spectral domain OCT(SD-OCT). AngioAnalytics software was used to estimate vessel densities of the ONH and peripapillary area. Predictive margins and linear mixed models were used to obtain average values and analyze the differences between groups. Pearson correlation was used for relationships between ONH characteristics and ONH vessel density. The study protocol was approved by Institutional Review Board.

Results : The two racial groups were well matched for age, sex, refractive error, and scan quality. Black subjects had significantly decreased radial peripapillary capillary (RPC) layer vessel density inside the disc (41.9±1.38 vs 48.6 1.13, p=0.01) and decreased flow area within RPC layer (1.39±0.03 vs 1.57±0.03, p=0.003). Black subjects had significantly larger cup volume (0.65±0.06 vs 0.38±0.05, p=0.014) and cup-to-disc ratio (CDR) (0.35±0.03 vs 0.24±0.02, p=0.032. Additionally, larger CDR was correlated with decreased vessel density inside the disc (-0.8682, p<0.0001). There was no difference between groups when comparing the vessel density of the RPC layer in the wider peripapillary area.

Conclusions : To our knowledge, this is the first report that shows vascular capillaries and anatomical variations of the ONH and peripapillary region between black and white populations, including decreased vessel density within the disc and decreased radial peripapillary capillary flow area. Although more research is needed, these differences may help to uncover the pathophysiology behind the increased incidence of glaucoma in black populations.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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