July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Interocular symmetry of foveal avascular zone area in healthy eyes: an examination using swept-source optical coherence tomography angiography
Author Affiliations & Notes
  • Atsushi Fujiwara
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Liu Mengxuan
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Yuki Morizane
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Mika Hosogi
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Shuhei Kimura
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Mio Hosokawa
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Yusuke Shiode
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Hirano Masayuki
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Shinichiro Doi
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Shinji Toshima
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Kosuke Takahashi
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Yuki Kanzaki
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Fumio Shiraga
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Okayama-ken, Japan
  • Footnotes
    Commercial Relationships   Atsushi Fujiwara, None; Liu Mengxuan, None; Yuki Morizane, None; Mika Hosogi, None; Shuhei Kimura, None; Mio Hosokawa, None; Yusuke Shiode, None; Hirano Masayuki, None; Shinichiro Doi, None; Shinji Toshima, None; Kosuke Takahashi, None; Yuki Kanzaki, None; Fumio Shiraga, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2882. doi:
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      Atsushi Fujiwara, Liu Mengxuan, Yuki Morizane, Mika Hosogi, Shuhei Kimura, Mio Hosokawa, Yusuke Shiode, Hirano Masayuki, Shinichiro Doi, Shinji Toshima, Kosuke Takahashi, Yuki Kanzaki, Fumio Shiraga; Interocular symmetry of foveal avascular zone area in healthy eyes: an examination using swept-source optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2882.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : One challenge in evaluating the influence of retinal vascular disease on foveal avascular zone (FAZ) area is that a standard procedure for determining a control value for FAZ area has not been established. Because individual differences in FAZ area are large (Fujiwara PLoS ONE 2017), the FAZ area of the healthy eyes of others is not appropriate for use as a control. One solution is to consider the FAZ area of the fellow eye as a control, particularly in the case of unilateral retinal vascular disease. However, the presence or absence of left/right differences in FAZ area of healthy fellow eyes is unknown. Therefore, we prospectively studied the FAZ area of healthy eyes using optical coherence tomography angiography (OCTA) and examined the presence or absence of left/right differences in fellow eyes.

Methods : We examined 236 eyes of 118 consecutive healthy subjects (70 females and 48 males, mean age, 39.1±18.9 years). The inclusion criteria for the eyes were a best corrected visual acuity of 20/20 or better and no history of ocular diseases. We captured OCTA images using swept-source OCT (DRI OCT-1, Topcon) and measured the FAZ area of the superficial capillary plexus using EnView software (Topcon). We analyzed the agreement of symmetry in the FAZ area of both eyes by paired t-test, Pearson's correlation coefficient, and Bland-Altman plots. We also measured axial length (AX), central retinal thickness (CRT), and retinal vascular density (RVD), and we performed multivariate regression analysis to investigate the relationships between the absolute interocular difference of FAZ area and these factors.

Results : There was no significant difference in the FAZ area between right and left eyes (0.32 ± 0.11 mm2, 0.31 ± 0.11 mm2, respectively, P = 0.608), and the right and left eyes were significantly and positively correlated with each other (P < 0.001, R2 = 0.884). Bland-Altman plots showed that the mean interocular difference of the FAZ area was 0.03 mm2 (95 % confidence interval, - 0.02 – 0.08 mm2). Multivariate regression analysis showed that age was significantly associated with the absolute interocular difference of FAZ area (P < 0.01, R2 = 0.138).

Conclusions : There was no interocular left/right difference in FAZ area in healthy eyes.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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