July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Study of predictive factors corneal failure on DMEK (Descemet Membrane Endothelial Keratoplasty).
Author Affiliations & Notes
  • Chloé DUBROUX
    Ophthalmology, Metz-Thionville Regional Hospital Center, Metz, France
    Faculty of Medicine, University of Lorraine, Nancy, France
  • Christophe Goetz
    Clinical Research Support Unit, Metz-Thionville Regional Hospital Center, Metz, France
  • LOUIS LHUILLIER
    Ophthalmology, Metz-Thionville Regional Hospital Center, Metz, France
  • Mohamed Zaidi
    Ophthalmology, Metz-Thionville Regional Hospital Center, Metz, France
  • Marie DA COSTA
    Ophthalmology, Metz-Thionville Regional Hospital Center, Metz, France
    Faculty of Medicine, University of Lorraine, Nancy, France
  • pauline ROLLAND
    Ophthalmology, Metz-Thionville Regional Hospital Center, Metz, France
    Faculty of Medicine, University of Lorraine, Nancy, France
  • Nadia Ouamara
    Clinical Research Support Unit, Metz-Thionville Regional Hospital Center, Metz, France
  • Jean-Marc Perone
    Ophthalmology, Metz-Thionville Regional Hospital Center, Metz, France
  • Footnotes
    Commercial Relationships   Chloé DUBROUX, None; Christophe Goetz, None; LOUIS LHUILLIER, None; Mohamed Zaidi, None; Marie DA COSTA, None; pauline ROLLAND, None; Nadia Ouamara, None; Jean-Marc Perone, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2898. doi:
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      Chloé DUBROUX, Christophe Goetz, LOUIS LHUILLIER, Mohamed Zaidi, Marie DA COSTA, pauline ROLLAND, Nadia Ouamara, Jean-Marc Perone; Study of predictive factors corneal failure on DMEK (Descemet Membrane Endothelial Keratoplasty).. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2898.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The main objective was to study the predictive factors of DMEK failure.

Methods : This is an observational, prospective and single-center study, including all patients who received a DMEK in our department from March 2014 to November 2017. The operative indications were mainly Fuchs dystrophies and keratopathies bullous. Were collected the following data : age of donors and recipients, sex, endothelial cell density (ECD) of grafts, operative time, type of phacoemulsification combined or not (triple procedure) and finally the marking or not of the stromal face of the graft. The primary endpoint was the graft failure, leading to the realization of a second transplant type reDMEK or DSAEK.

Results : Seventy three eyes of 56 patients were included, 48 women (66%) and 18 men (34%). The average age of recipients was 73 years (SD 10), and 75 years (SD 13) for the donors. The operating time was 36 min (SD 10). The number of triple procedure was 18 (25%). 18 grafts (25%) were marked. There were 16 failures (22%). In bivariate or multivariate analysis, the results on the primary endpoint were not statistically significant for all the criteria studied (age, sex, DCE, triple procedure and graft tagging). The stromal staining of the graft was nevertheless associated with 88% success, against only 74% for the unmarked grafts but this difference remained insignificant, because of the small sample size.

Conclusions : This study does not reveal any predictive factors for corneal transplant failure of the DMEK type. A multicenter, larger scale study may be needed.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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