July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Efficacy of Collagen Matrix Implant on Adhesions in Restrictive Strabismus: An Experimental Study in a Rabbit Model
Author Affiliations & Notes
  • Yung Ju Yoo
    Ophthalmology, Kangwon National University Hospital, Chuncheon-si, Gangwon-do, Korea (the Republic of)
  • Hee Kyung Yang
    Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Seung Jun Lee
    Ophthalmology, Kangwon National University Hospital, Chuncheon-si, Gangwon-do, Korea (the Republic of)
  • Jeong-Min Hwang
    Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Yung Ju Yoo, None; Hee Kyung Yang, None; Seung Jun Lee, None; Jeong-Min Hwang, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2933. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Yung Ju Yoo, Hee Kyung Yang, Seung Jun Lee, Jeong-Min Hwang; Efficacy of Collagen Matrix Implant on Adhesions in Restrictive Strabismus: An Experimental Study in a Rabbit Model. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2933.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To evaluate the efficacy of a biodegradable collagen matrix implant (Ologen, Aeon Astron Europe BV, Leiden, The Netherlands) in reducing adhesions in a rabbit model of restrictive strabismus.

Methods : SETTING: Prospective, masked-observer, controlled experimental study. STUDY POPULATION: Sixty superior rectus muscles of 30 rabbits. INTERVENTION: Each superior rectus muscle was resected and Marlex mesh was fixed beneath the resected muscle using nonabsorbable sutures. Forty eyes underwent one of two different procedures: the resected muscle was wrapped with cryopreserved human amniotic membrane (AM group) or Ologen (Ologen group). Randomly selected 20 eyes served as a control. MAIN OUTCOME MEASURES: Eyes were enucleated at four weeks after surgery to measure the stability of the bond using a push pull gauge and to perform histopathological examination.

Results : At postoperative week four, the average tensile strength of the myoscleral adhesion was significantly lower in the Ologen group (151.8 ± 42.7 gram force) compared to controls (347.9 ± 68.6 gram force) and the AM group (193.0 ± 44.3 gram force) (P<0.001 and P=0.045, respectively). The Ologen group showed significantly lower degree of acute inflammation, chronic inflammation, and rectus muscle fibrosis compared with controls (all P<0.01). The degree of chronic inflammation was significantly lower in the Ologen group compared with the AM group (P=0.012).

Conclusions : Ologen is more effective in reducing mesh-related extraocular muscle adhesions compared to amniotic membrane in a rabbit model of restrictive strabismus.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×