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Yung Ju Yoo, Hee Kyung Yang, Seung Jun Lee, Jeong-Min Hwang; Efficacy of Collagen Matrix Implant on Adhesions in Restrictive Strabismus: An Experimental Study in a Rabbit Model. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2933.
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To evaluate the efficacy of a biodegradable collagen matrix implant (Ologen, Aeon Astron Europe BV, Leiden, The Netherlands) in reducing adhesions in a rabbit model of restrictive strabismus.
SETTING: Prospective, masked-observer, controlled experimental study. STUDY POPULATION: Sixty superior rectus muscles of 30 rabbits. INTERVENTION: Each superior rectus muscle was resected and Marlex mesh was fixed beneath the resected muscle using nonabsorbable sutures. Forty eyes underwent one of two different procedures: the resected muscle was wrapped with cryopreserved human amniotic membrane (AM group) or Ologen (Ologen group). Randomly selected 20 eyes served as a control. MAIN OUTCOME MEASURES: Eyes were enucleated at four weeks after surgery to measure the stability of the bond using a push pull gauge and to perform histopathological examination.
At postoperative week four, the average tensile strength of the myoscleral adhesion was significantly lower in the Ologen group (151.8 ± 42.7 gram force) compared to controls (347.9 ± 68.6 gram force) and the AM group (193.0 ± 44.3 gram force) (P<0.001 and P=0.045, respectively). The Ologen group showed significantly lower degree of acute inflammation, chronic inflammation, and rectus muscle fibrosis compared with controls (all P<0.01). The degree of chronic inflammation was significantly lower in the Ologen group compared with the AM group (P=0.012).
Ologen is more effective in reducing mesh-related extraocular muscle adhesions compared to amniotic membrane in a rabbit model of restrictive strabismus.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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