July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Retinal Metabolism in Aging and Disease
Author Affiliations & Notes
  • Rajendra Apte
    Ophthalmology, Washington Univ - St Louis, Saint Louis, Missouri, United States
  • Footnotes
    Commercial Relationships   Rajendra Apte, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2972. doi:
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    • Get Citation

      Rajendra Apte; Retinal Metabolism in Aging and Disease. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2972.

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      © ARVO (1962-2015); The Authors (2016-present)

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Presentation Description :
Disorders of lipid metabolism and macrophage function have been implicated in tissue aging and in diseases such as AMD. Genetic studies and expression profiling have identified widespread abnormalities in cholesterol metabolism in the aging macrophage. In addition, the molecular pathways that regulate the transition from aging to disease have not been elucidated. The current status regarding the mechanisms that regulate macrophage aging and the molecular mechanisms of transition to disease in the context of AMD will be presented with a special focus on factors that influence pathologic angiogenesis and neurodegeneration

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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