July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Optical Quality After In Vitro Intraocular Lens Power Adjustment Using a Femtosecond Laser
Author Affiliations & Notes
  • Jason Nguyen
    University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
    John A. Moran Eye Center, Salt Lake City, Utah, United States
  • Liliana Werner
    John A. Moran Eye Center, Salt Lake City, Utah, United States
  • Joah Aliancy
    John A. Moran Eye Center, Salt Lake City, Utah, United States
  • Jason Ludlow
    John A. Moran Eye Center, Salt Lake City, Utah, United States
  • Bryan Masino
    John A. Moran Eye Center, Salt Lake City, Utah, United States
  • Larry Ha
    John A. Moran Eye Center, Salt Lake City, Utah, United States
  • Sean Enright
    Perfectlens, Irvine, California, United States
  • Ray Alley
    Perfectlens, Irvine, California, United States
  • Ruth Sahler
    Perfectlens, Irvine, California, United States
  • Nick Mamalis
    John A. Moran Eye Center, Salt Lake City, Utah, United States
  • Footnotes
    Commercial Relationships   Jason Nguyen, None; Liliana Werner, Perfectlens (F); Joah Aliancy, None; Jason Ludlow, None; Bryan Masino, None; Larry Ha, None; Sean Enright, Perfectlens (E); Ray Alley, Perfectlens (E); Ruth Sahler, Perfectlens (E); Nick Mamalis, Perfectlens (F)
  • Footnotes
    Support  Study supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, NY, USA to the Department of Ophthalmology and Visual Sciences, University of Utah, and by a research grant from Perfect Lens LLC, Irvine, CA, USA.
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2980. doi:
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      Jason Nguyen, Liliana Werner, Joah Aliancy, Jason Ludlow, Bryan Masino, Larry Ha, Sean Enright, Ray Alley, Ruth Sahler, Nick Mamalis; Optical Quality After In Vitro Intraocular Lens Power Adjustment Using a Femtosecond Laser. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2980.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this study was to evaluate intraocular lens (IOL) power, modulation transfer function (MTF), light transmission, as well as light scattering of commercially available IOLs before and after different types of adjustment by femtosecond laser. The use of a femtosecond laser to alter the hydrophilicity of targeted areas within an IOL creates the ability to build a refractive index shaping lens within an existing IOL.

Methods : Ten commercially available single-piece, hydrophobic acrylic yellow IOLs, as well as commercially available clear (non-yellow) hydrophobic acrylic monofocal and multifocal IOLs were used in this study. The 10 yellow lenses underwent power adjustment targeted at -2.0 D. The non-yellow monofocal lenses underwent refractive and multifocal adjustments, while the multifocal lenses underwent multifocality cancellation. IOL power and MTF were measured with a Lambda-X PMTF device. Light transmission was measured using a PerkinElmer Lambda 35 UV/Vis spectrophotometer. Back light scattering was assessed with a Scheimpflug camera, at the anterior and posterior surfaces, as well as within the IOL substance.

Results : After laser adjustment, a mean power change of -2.037 D was associated with a MTF change of -0.064, and a light transmittance change of -1.4% in the 10 yellow lenses. Back light scattering increased within the lens in the zone corresponding to the laser treatment at levels not expected to cause any clinical impact. Refractive and multifocal adjustments of non-yellow monofocal lenses were also precise and associated with minimal changes of the optical parameters evaluated. Cancellation of the multifocality of a commercially available multifocal IOL could be obtained with improvement of the MTF.

Conclusions : Power adjustment of commercially available hydrophobic lenses by femtosecond laser produces an accurate change in dioptric power while not significantly affecting the quality of the IOL optic, as assessed by MTF, light transmission, and light scattering measurements.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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