July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
In Vivo Intraocular Lens Power Adjustment Using a Femtosecond Laser in the Rabbit Model
Author Affiliations & Notes
  • Liliana Werner
    Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, United States
  • Jason Ludlow
    Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, United States
  • Jason Nguyen
    Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, United States
  • Joah Aliancy
    Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, United States
  • Nathan Ellis
    Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, United States
  • Joshua Heczko
    Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, United States
  • Bill Jiang
    Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, United States
  • Telyn Peterson
    Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, United States
  • Sean Enright
    Perfect Lens LLC, Irvine, California, United States
  • Ray Alley
    Perfect Lens LLC, Irvine, California, United States
  • Ruth Sahler
    Perfect Lens LLC, Irvine, California, United States
  • Nick Mamalis
    Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, United States
  • Footnotes
    Commercial Relationships   Liliana Werner, Perfect Lens LLC (F); Jason Ludlow, None; Jason Nguyen, None; Joah Aliancy, None; Nathan Ellis, None; Joshua Heczko, None; Bill Jiang, None; Telyn Peterson, None; Sean Enright, Perfect Lens LLC (E); Ray Alley, Perfect Lens LLC (E); Ruth Sahler, Perfect Lens LLC (E); Nick Mamalis, Perfect Lens LLC (F)
  • Footnotes
    Support  Study supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, NY, USA to the Department of Ophthalmology and Visual Sciences, University of Utah, and by a research grant from Perfect Lens LLC, Irvine, CA, USA.
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2981. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Liliana Werner, Jason Ludlow, Jason Nguyen, Joah Aliancy, Nathan Ellis, Joshua Heczko, Bill Jiang, Telyn Peterson, Sean Enright, Ray Alley, Ruth Sahler, Nick Mamalis; In Vivo Intraocular Lens Power Adjustment Using a Femtosecond Laser in the Rabbit Model. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2981.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : We evaluated the uveal and capsular biocompatibility of intraocular lens (IOL) power adjustment by a femtosecond laser in two in vivo studies using the rabbit model: a 4-week, short-term study, and a 6-month, long-term study.

Methods : In the short-term study, 6 New Zealand rabbits underwent phacoemulsification with bilateral implantation of a commercially available hydrophobic acrylic IOL. Postoperative power adjustment was performed 2 weeks following implantation, in one eye of each rabbit. The animals were then followed clinically for an additional 2 weeks, and humanely euthanized. Their globes were enucleated and bisected coronally just anterior to the equator for gross examination from the Miyake-Apple view, to assess capsular bag opacification. After IOL explantation for power measurements, the globes were sectioned and processed for standard histopathology. In the long-term study, 8 rabbits underwent phacoemulsification with bilateral implantation of another commercially available hydrophobic acrylic IOL. Power adjustment was performed 2 weeks following implantation, in one eye of each rabbit. The animals were then followed clinically for 6 months, followed by euthanasia, and pathological evaluation.

Results : Slit lamp examination performed after laser treatment showed no postoperative inflammation or toxicity in the treated eyes, and postoperative outcomes, as well as histopathological exams were similar to the non-treated eyes in both short- and long-term studies. Power measurements showed that the change in power obtained was consistent and within 0.1 diopter of the target.

Conclusions : The use of a femtosecond laser to alter the hydrophilicity of targeted areas within an IOL creates the ability to build a refractive index shaping (RIS) lens within an existing IOL. Consistent and precise power changes can be induced in the optic of commercially available lenses in vivo, by using a femtosecond laser to create a RIS lens. Results up to 6 months postoperatively showed that the laser treatment of the IOLs was biocompatible in the rabbit model, without any signs of toxicity.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×