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Liliana Werner, Jason Ludlow, Jason Nguyen, Joah Aliancy, Nathan Ellis, Joshua Heczko, Bill Jiang, Telyn Peterson, Sean Enright, Ray Alley, Ruth Sahler, Nick Mamalis; In Vivo Intraocular Lens Power Adjustment Using a Femtosecond Laser in the Rabbit Model. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2981.
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© ARVO (1962-2015); The Authors (2016-present)
We evaluated the uveal and capsular biocompatibility of intraocular lens (IOL) power adjustment by a femtosecond laser in two in vivo studies using the rabbit model: a 4-week, short-term study, and a 6-month, long-term study.
In the short-term study, 6 New Zealand rabbits underwent phacoemulsification with bilateral implantation of a commercially available hydrophobic acrylic IOL. Postoperative power adjustment was performed 2 weeks following implantation, in one eye of each rabbit. The animals were then followed clinically for an additional 2 weeks, and humanely euthanized. Their globes were enucleated and bisected coronally just anterior to the equator for gross examination from the Miyake-Apple view, to assess capsular bag opacification. After IOL explantation for power measurements, the globes were sectioned and processed for standard histopathology. In the long-term study, 8 rabbits underwent phacoemulsification with bilateral implantation of another commercially available hydrophobic acrylic IOL. Power adjustment was performed 2 weeks following implantation, in one eye of each rabbit. The animals were then followed clinically for 6 months, followed by euthanasia, and pathological evaluation.
Slit lamp examination performed after laser treatment showed no postoperative inflammation or toxicity in the treated eyes, and postoperative outcomes, as well as histopathological exams were similar to the non-treated eyes in both short- and long-term studies. Power measurements showed that the change in power obtained was consistent and within 0.1 diopter of the target.
The use of a femtosecond laser to alter the hydrophilicity of targeted areas within an IOL creates the ability to build a refractive index shaping (RIS) lens within an existing IOL. Consistent and precise power changes can be induced in the optic of commercially available lenses in vivo, by using a femtosecond laser to create a RIS lens. Results up to 6 months postoperatively showed that the laser treatment of the IOLs was biocompatible in the rabbit model, without any signs of toxicity.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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