July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Prediction of lens compliance and accommodative amplitude based on color index of the lens.
Author Affiliations & Notes
  • Henk A Weeber
    R & D, AMO Groningen BV, Groningen, Netherlands
  • Bram Koopman
    R & D, AMO Groningen BV, Groningen, Netherlands
  • Patricia Piers
    R & D, AMO Groningen BV, Groningen, Netherlands
  • Footnotes
    Commercial Relationships   Henk Weeber, AMO Groningen b.v. (E); Bram Koopman, AMO Groningen b.v. (E); Patricia Piers, AMO Groningen b.v. (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3030. doi:
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      Henk A Weeber, Bram Koopman, Patricia Piers; Prediction of lens compliance and accommodative amplitude based on color index of the lens.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3030.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To explore the correlation between lens color and lens compliance and accommodative amplitude.

Methods : The human crystalline lens shows a yellow color, which becomes more pronounced with age. Studies on mechanical properties of the lens material have shown that lens color is a predictor of the compliance of the lens material.
The accommodative amplitude as a function of compliance was determined using a mechanical finite element model. The compliance was predicted based on the color of the lens.
The yellow color of lenses was assessed subjectively, based on a color scale of 10 grades of yellow. In this study, the variation of compliance and accommodative amplitude, and its correlation with the yellow coloring of the lens was investigated.

Results : As expected, the accommodative amplitude, as calculated by the FE model, decreases with increasing yellowing of the lens. The correlation between accommodative amplitude and grade of yellow color was close to linear (R2≈0.99). The confidence interval and the prediction interval of the logarithm of the compliance (log Jeo) were 0.5kPa-1 and 1.5kPa-1, respectively. These intervals were independent of the yellow color grade. As a result, the uncertainty (interval of the 90% prediction band) in terms of shear modulus increases exponentially as a function of yellow grade, being on the order of 1 kPa for soft lenses and 100 kPa for hard lenses.

Conclusions : The compliance (log Jeo) and the accommodative amplitude can be well predicted based on the yellow coloring of the crystalline lens. However, the prediction of the shear modulus suffers from a large prediction error for hard (old) lenses.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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