July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Natural course, intravitreal bevacizumab injection responsiveness and OCT angiography (OCTA) findings of central serous chorioretinopathy patients; flat pigment epithelium detachment (PED) Vs focal PED
Author Affiliations & Notes
  • Dong Yoon Kim
    Ophthalmology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea, Cheongju, Korea (the Republic of)
  • Ju Byung Chae
    Ophthalmology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea, Cheongju, Korea (the Republic of)
  • Young Min Park
    Department of Ophthalmology, ChangWon Gyeongsang National University Hospital, College of Medicine, Gyeongsang National University, ChangWon, Korea, ChangWon, Korea (the Republic of)
  • Jisoo Kim
    Ophthalmology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea, Cheongju, Korea (the Republic of)
  • Jin Young Kim
    Department of Ophthalmology, Jeju National University Hospital, College of Medicine, Jeju National University, Jeju, Korea, Jeju, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Dong Yoon Kim, None; Ju Byung Chae, None; Young Min Park, None; Jisoo Kim, None; Jin Young Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3125. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Dong Yoon Kim, Ju Byung Chae, Young Min Park, Jisoo Kim, Jin Young Kim; Natural course, intravitreal bevacizumab injection responsiveness and OCT angiography (OCTA) findings of central serous chorioretinopathy patients; flat pigment epithelium detachment (PED) Vs focal PED. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3125.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To investigate the differences in natural course, intravitreal bevacizumab injection (IVB) responsiveness and OCTA findings according to the type of pigment epithelium detachment (PED) in patients with central serous chorioretinopathy (CSC).

Methods : Retrospective review was conducted to the patients with CSC who were able to follow up more than 3 months. Patients were classified as flat PED and focal PED according to the pattern of PED. The symptom duration, central retinal thickness, subfoveal choroidal thickness (SFChT), presence of subretinal fluid, natural course and OCTA findings were compared between two group. When subretinal fluid did not improve after 3 months, IVB injection was performed. And IVB responsiveness according to the PED type was also compared.

Results : Out of 224 patients diagnosed with CSC from November 2013 to June 2017, 100 eyes (64 eyes with flat PED vs 34 eyes with focal PED). The flat PED group had a longer symptom duration than the focal PED group (7.20±11.52 Vs 3.69±3.98 month, P=0.03). The SFChT of flat PED group was significantly thicker 32 eyes in the flat PED group and 17 eyes in the focal PED group were observed without any treatment. The rate of complete resolution of SRF was significantly lower in the flat PED group than in the focal PED group (46.9% Vs 82.4%, P=0.02). However, in contrast to natural course, responsiveness to IVB was better in the flat PED group (72.41 % Vs 26.32 %, P<0.01). In the flat PED group, hidden choroidal neovascularization (CNV) was detected in OCTA, although CNV was not detected by fluorescein angiography and indocyanine green angiography and diagnosed as CSC.

Conclusions : Patients with CSC who had flat PED showed longer duration of symptoms and thicker SFChT than those with focal PED. The rate of complete resolution of subretinal fluid without treatment was higher in the focal PED group. However, responsiveness to IVB was better in the flat PED group. Hidden CNV was detected by OCTA in flat PED group. This finding suggests that vascular endothelial growth factor may more contribute to the pathogenesis of flat PED in CSC patients.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×