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Gerald Seidel, Christoph Singer, Sereina Annik Herzog, Gerhard Garhofer, Leopold Schmetterer; Retinal vessel diameter measurement in multimodal imaging. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3199.
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© ARVO (1962-2015); The Authors (2016-present)
To elucidate differences in retinal vessel diameter measurements between optical coherence tomography (OCT), fluorescein angiography (FLA), and fundus photography.
In this single center cross sectional study multimodal imaging was obtained from 50 eyes of 50 subjects. Arterial and venous diameters were assessed half a disc diameter away from the disc using spectral domain optical coherence tomography, mid-phase fluorescein angiography, and digital color fundus photography. From these we analyzed differences in average vessel diameter differences using a linear mixed model and compared the central retinal artery equivalent (CRAE), the central retinal vein equivalent (CRVE), und the arteriovenous ratio (AVR).
With all 3 methods 699 from 725 vessel could be imaged. The average vessels diameter was 91.2±34.4 µm with FLA, 82.7±30.2 µm with photography, and 80.3±30.9 µm with OCT. The difference was similar for arteries and veins. Based on photography the interclass correlation coefficient was 0.084 for FLA and 0.505 for OCT.The mean CRAE was 156.5±22.6 µm in FLA, 142.9±15.3 µm with OCT, 144.9 ± 20.1 µm with photo. The mean CRVE was 241.8±36.2 µm with FLA, 211.8±18.9 µm with OCT, 216.2±34.0 µm with photo. The AVR was 0.7±0.1 for all imaging modalities.
Retinal vessel diameter measurements differ significantly between imaging modalities, especially between OCT and camera based modalities.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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