July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Systemic Classification of Neovascular Age-related Macular Degeneration using Indocyanine Green Angiography: a Clinical Significance
Author Affiliations & Notes
  • Kunho Bae
    Ophthalmology, Kyung Hee University Hospital, Seoul, Korea (the Republic of)
    Samsung Medical Center, Seoul, Korea (the Democratic People's Republic of)
  • Sung Rae Noh
    Ophthalmology, Kyung Hee University Hospital, Seoul, Korea (the Republic of)
  • Jae Min Kim
    Ophthalmology, Kyung Hee University Hospital, Seoul, Korea (the Republic of)
  • Kiyoung Kim
    Ophthalmology, Kyung Hee University Hospital, Seoul, Korea (the Republic of)
  • Eung-Suk Kim
    Ophthalmology, Kyung Hee University Hospital, Seoul, Korea (the Republic of)
  • Seung-Young Yu
    Ophthalmology, Kyung Hee University Hospital, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Kunho Bae, None; Sung Rae Noh, None; Jae Min Kim, None; Kiyoung Kim, None; Eung-Suk Kim, None; Seung-Young Yu, None
  • Footnotes
    Support  National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1D1A1B03034695).
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3219. doi:
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      Kunho Bae, Sung Rae Noh, Jae Min Kim, Kiyoung Kim, Eung-Suk Kim, Seung-Young Yu; Systemic Classification of Neovascular Age-related Macular Degeneration using Indocyanine Green Angiography: a Clinical Significance. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3219.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To propose a novel classification of neovascular age-related macular degeneration (AMD) based on the indocyanine green angiography (ICGA) and compare the optical coherence tomography (OCT) findings and visual outcomes.

Methods : This study involved treatment naïve consecutive patients with neovascular AMD. Subtypes were classified based on ICGA and fluorescein angiography (FA) characteristics. Best-corrected visual acuity (BCVA) and OCT findings were analyzed at baseline and 12 months after initial visit.

Results : Among 353 eyes, 5 AMD subtypes were seen: 1) classic choroidal neovascularization (CNV): 12.1%, 2) occult CNV: 8.8%, 3) microaneurysmal choroidal vasculopathy (MCV): 26.8%, 4) polypoidal choroidal vasculopathy (PCV): 36.6%, and 5) retinal angiomatous proliferation (RAP): 15.9%. Baseline mean BCVA was highest in PCV, and lowest in classic CNV (20/160, 20/125, 20/100, 20/90, 20/140, in numerical order, p = .385). Central macular subfield thickness was highest in RAP, and lowest in classic CNV (287.8, 328.9, 298.4, 309.5, 348.9, in numerical order, p = .036). Subfoveal choroidal thickness was highest in MCV, and lowest in RAP (145.5, 183.5, 273.8, 232.8, 125.4, in numerical order, p < .001). There was no difference in treatment modality, but there was significant difference of final BCVA at 12 months (20/140, 20/100, 20/80, 20/60, 20/120, in numerical order, p = .046).

Conclusions : The classification system of this study consisted with classic CNV, occult CNV, MCV, PCV, and RAP based on ICGA findings. There was angiographic resemblance between MCV and PCV, but clinical outcome of MVP was similar to occult CNV.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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