July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Evaluating Retinal Angiomatous Proliferation With Optical Coherence Tomography Angiography
Author Affiliations & Notes
    Wenzhou Medical University, Hangzhou, China
  • Jianbo Mao
    Wenzhou Medical University, Hangzhou, China
  • Footnotes
    Commercial Relationships   LIJUN SHEN, None; Jianbo Mao, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3228. doi:
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      LIJUN SHEN, Jianbo Mao; Evaluating Retinal Angiomatous Proliferation With Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3228.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To report the imaging features of different stage of retinal angiomatous proliferation (RAP) on optical coherence tomography angiography (OCTA).

Methods : Treatment-naive patients diagnosed with RAP were included in this retrospective study. All patients underwent fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography (OCT), and OCTA. The OCTA features were illustrated and compared with FA, ICGA or OCT. OCTA was performed at baseline and after the injection of anti-vascular endothelial growth factor (VEGF), PDT or combined.

Results : A total ten treatment-native eyes of ten consecutive patients, were included, from 57 to 82 years old. In all cases, the hot spot lesions found on late FA or ICGA images, were clearly detected on OCTA images on the same area (10/10, 100%). Hot spot lesions showed variable patterns. Four patients had multiple hot spot lesions, located on outer retina layer, deep layer or superior retinal layer. OCTA showed clearer location and relationship with the feeder vessels than FA or ICGA. Eight patients had received anti-VEGF therapy 2.13±0.83 times and one patient had Anti-VEGF combined with photodynamic therapy (PDT) for once. Follow-up OCTA images demonstrated smaller and less hot spot lesion, with lower blood flow signal.

Conclusions : Optical coherence tomography angiography is a noninvasive fast imaging modality for detecting vascular changes in RAP. Hot spot lesion and relative vessels showed more clearly on OCTA than on ICGA or FA. The OCTA patterns of hot spot maybe helpful in understanding the pathology of RAP. And OCTA would be a valuable tool to the follow up observation.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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