July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Visual field characteristic comparison between MS-ON and NMO-ON: Six months follow-up after acute onset

Author Affiliations & Notes
  • Hui Yang
    Fundus disease/neuro-ophthalmology, Zhongshan ophthalmic center, Guangzhou, Guangdong, China
  • Footnotes
    Commercial Relationships   Hui Yang, None
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Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3367. doi:
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      Hui Yang; Visual field characteristic comparison between MS-ON and NMO-ON: Six months follow-up after acute onset

      . Invest. Ophthalmol. Vis. Sci. 2018;59(9):3367.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Through comparison of the visual field change of Multiple sclerosis related optic neuritis(MS-ON) and neuromyelitis optica related optic neuritis(NMO-ON), from onset to 6m after , to better understand the precise involvement in optic nerve.

Methods : Prospective, single-center, case-control study. 54 cases of MS-ON and 27 cases of NMO-ON were included. MD(mean defect) and PSD(pattern standard deviation) of VF at onset,1m,3m,6m after onset were analyzed.

Results : Results: For VF pattern: At the onset,diffuse abnormalities were the most common pattern in both group(P>0.05).One month after attack, central abnormalities began to arise in MS-ON(13%;P=0.031).The ratio of nerve fiber bundle abnormalities and diffuse abnormalities of the two groups was higher than the previous stage(22.9%,31.4% versus 22.5%,30%),of which 14.3% and 1.3% were altitudinal defcits in NMO-ON and MS-ON(P=0.015).The proportion of neurologic abnormalities in NMO-ON went up than before as well.Three quadrant abnormalities were found in 8.6% of the MS-ON eyes versus 0 of the NMO-ON eyes (P=0.027).Three months after attack, central abnormalities and normal VF was found in NMO-ON(8.6%,2.9%),while the other VF pattern had no obvious change between the two groups.Six months after attack,?% of normal visual field was found in MS-ON, while still no normal pattern was observed in the NMO-ON group(P=0.01).For VF MD & PSD: MD & PSD in the NMO-ON group was found higher than the MS-ON group,especially in 1 month and 6 to 12 months after attack(-18.7,-13.86 versus -11.9,-7.43;P=0.02,P=0.005).

Conclusions : Conclusion: VF recovery were quicker and better in MS-ON than NMO-ON. Diffuse damage was the most common in NMO-ON ,while Central and paracentral was the most common in MS-ON. Partial hemianopia was only found in NMO-ON. Altitudial heminopia were more frequent in NMO-ON, while arcuate defect was more frequent in MS-ON .

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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