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Na Rae Kim, Hee Seung Chin, Jung Yong Kim; Melatonin levels in patients with primary open angle glaucoma with high or low intraocular pressure. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3503. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate circulatory melatonin levels by assessing nocturnal urinary excretion of 6-sulfatoxymelatonin (aMT6s) in patients with primary open angle glaucoma (POAG) and to compare the high-tension group and the low-tension group.
This study included 41 POAG patients and 44 control subjects. POAG group was further classified into high-tension group and low-tension group according to the pretreatment intraocular pressure. The first urine in the morning was collected and aMT6s were measured using a commercial ELISA kit. Urinary aMT6s levels were expressed as ng aMT6s/mg creatinine. Differences in melatonin levels among the control and POAG subgroups were evaluated by generalized estimating equation adjusting age, sex, sleep duration, and inter-eye correlation.
Urinary aMT6s/creatinine ratio did not differ between POAG and control group (P = 0.097). The difference in the aMT6s/creatinine ratio between the three groups— high-tension group with baseline intraocular pressure (IOP) ≥ 21 mmHg (19.74 ± 14.44 ng/mg), low-tension glaucoma group with baseline IOP < 21 mmHg (26.71 ± 16.91 ng/mg), and control group (30.35 ± 30.51 ng/mg)—was statistically significant (p = 0.046). Post hoc analysis revealed that the difference between the control and high-tension glaucoma groups was significant (p = 0.014), while the difference between the control and low-tension glaucoma groups was not (p = 0.436).
This study found low melatonin levels in high-tension glaucoma and high melatonin levels in low-tension glaucoma.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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