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Yayi Wang, Shida Chen, Yaoming Liu, Hao Li, Yang Chen, Xiulan Zhang; Inflammatory Cytokine Profiles in Eyes with Primary Angle-Closure Glaucoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3522. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Previous researches showed that an early acute inflammatory condition occurs in the aqueous humor of eyes with acute primary angle-closure (APAC). We performed this cross-sectional study to evaluate the role of inflammation related cytokines in the pathogenesis of primary angle closure glaucoma (PACG).
This cross-sectional study involved 41 eyes of 33 patients with PACG which required surgery treatment and 15 eyes of 15 control cataract patients. Aqueous humor was collected at the time of surgery. The 15 inflammation related cytokines were detected by the multiple bead immunoassay technique. Clinical information was recorded for correlation analysis.
Among the 15 inflammation related cytokines, only 8 cytokines could be detected in both groups including granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-6, IL-8, monocyte chemotactic protein (MCP)-1, MCP-3, macrophage-derived chemokine (MDC), macrophage inflammatory protein (MIP)-1β and vascular endothelial growth factor (VEGF). Compared with cataract patients, the levels of IL-6, IL-8, MCP-1 and MIP-1β were decreased in the aqueous of PACG patients (all p<0.05), while the cytokine of MDC was elevated in PACG patients (p<0.05). The concentration of MCP-1 was elevated accordingly when the disease progressed in PACG patients (p=0.016). MCP-1 level was related to the extent of peripheral anterior synechiae, although not reach a statistically significance (p=0.278). The PACG patients on prostaglandin has higher level of MIP-1β in aqueous humor than patients used other drugs (P=0.033). Other anti-glaucoma drugs were not related to the level of cytokines in the aqueous (p>0.05).
PACG eyes retained a low inflammation condition in the aqueous, MCP-1 may play an important role in the progress of the disease and the development of peripheral anterior synechiae.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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