July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Advanced glycation end-products as a marker of accelerated ageing in primary open angle glaucoma
Author Affiliations & Notes
  • Leanne Smewing
    Eye and Vision Research Group, Plymouth University, Plymouth, United Kingdom
  • Desley White
    Dietetics Research , Plymouth University, Plymouth, United Kingdom
  • Paul Artes
    Eye and Vision Research Group, Plymouth University, Plymouth, United Kingdom
  • Adam Booth
    Royal Eye Infirmary, Plymouth NHS Trust, Plymouth, United Kingdom
  • Stephanie Mroczkowska
    Eye and Vision Research Group, Plymouth University, Plymouth, United Kingdom
  • Footnotes
    Commercial Relationships   Leanne Smewing, None; Desley White, None; Paul Artes, None; Adam Booth, None; Stephanie Mroczkowska, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3724. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Leanne Smewing, Desley White, Paul Artes, Adam Booth, Stephanie Mroczkowska; Advanced glycation end-products as a marker of accelerated ageing in primary open angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3724.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Advanced glycation end products (AGEs) contribute to accelerated ageing of cells and tissues, and are known to accumulate in and around the optic nerve head. Accelerated ageing has been previously linked to the pathogenesis of a number of neurodegenerative diseases, including primary open angle glaucoma (POAG). The purpose of this study was to investigate whether AGE levels, as a marker of accelerated ageing, are elevated in early stage POAG.

Methods : Skin autofluorescence (SAF), as a validated measure of tissue-bound AGE levels, was assessed in 20 healthy early stage POAG patients and 36 age and body mass index (BMI) matched healthy controls (AGE Reader, DiagnOptics B.V., Groningen, The Netherlands). Dietary intake of exogenously derived AGEs was evaluated using a specifically designed food frequency questionnaire. Fasting blood glucose levels and blood pressure (BP) were recorded as potential covariates.

Results : POAG patients had a significantly higher SAF level (11% higher, confidence interval 2% to 20%, p=0.02) in comparison to healthy control participants, however there was no significant difference in dietary AGE values between the two groups (p=0.40). Age, BMI, BP and fasting blood glucose levels were comparable across the POAG and healthy control participants.

Conclusions : Tissue-bound AGE levels were found to be increased in patients diagnosed with early POAG. This adds to the evidence that accelerated ageing of ocular tissues may be a factor in the pathogenesis of the disease. Further research is needed to explore the association between AGEs, oxidative stress, and mechanical and vascular changes, to determine the full potential of AGEs as a biomarker for glaucoma.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×