Abstract
Purpose :
Retinal detachment (RD) can develop from retinopathy of prematurity (ROP) despite treatment for Type 1 ROP. We sought to determine the prevalence, timing, and risk factors for RD from ROP.
Methods :
Retrospective G-ROP Study at 29 North-American hospitals between 2006-2012. Primary outcomes were prevalence of eyes developing RD (stage 4 or 5) and onset post-treatment. Birth weight (BW), gestational-age, postnatal-weight gain, surgical necrotizing enterocolitis (NEC), sepsis, and days of oxygen supplementation were evaluated as risk factors among treated eyes using multivariable regression.
Results :
RD developed in 70/14,996 eyes (0.47%, 95% CI 0.37-0.59%) and 46/7,483 infants (0.61%); 37 stage 4, 33 stage 5; 52% had bilateral RD. 6 eyes/3 infants developed RD without Type 1 ROP diagnosis or treatment. 64/885 eyes developed RD following laser (7.2%, 5.8-9.3%): 56/742 Type 1, 8/128 Type 2. RD occurred at median 5.6 weeks (range 0.7-19 weeks) following treatment. 10 (15.6%) RD’s were within 2 weeks of treatment. Number treated within 72 hours of Type 1 diagnoses was similar between RD and non-RD eyes. In multivariable analysis, lower BW (OR 1.03 per-10 gram-decrease (1.01-1.05)) and NEC (OR 3.0, 1.5-5.9) were significant risk factors for RD following treatment. RD rates were, for example, 11.9% for BW<500g without NEC; 16.9% for BW<700g with NEC.
Conclusions :
7.2% of eyes progress to RD despite treatment for ROP. Infants with low BW and/or NEC are at increased risk for RD. Identification of infants at increased risk for RD could lead to modifications of treatment criteria or timing for such infants.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.