July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Statistical analysis for development of myopia in 1-year-old patients treated with laser photocoagulation for retinopathy of prematurity (ROP)
Author Affiliations & Notes
  • Shinichiro Kawai
    Dept. of Ophthalmology, Saitama Medical Center, Saitama Medical University, Saitama, Japan
  • Ayako Marubayashi
    Dept. of Ophthalmology, Saitama Medical Center, Saitama Medical University, Saitama, Japan
  • Hiroto Obata
    Dept. of Ophthalmology, Saitama Medical Center, Saitama Medical University, Saitama, Japan
  • Footnotes
    Commercial Relationships   Shinichiro Kawai, None; Ayako Marubayashi, None; Hiroto Obata, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3768. doi:
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      Shinichiro Kawai, Ayako Marubayashi, Hiroto Obata; Statistical analysis for development of myopia in 1-year-old patients treated with laser photocoagulation for retinopathy of prematurity (ROP). Invest. Ophthalmol. Vis. Sci. 2018;59(9):3768.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Laser photocoagulation (PC) is still the main treatment for retinopathy of prematurity (ROP). As a complication of this treatment, it is well known that high myopia frequently occurs from an early stage under 1 year of age, but this mechanism has not been clarified. We investigated any risk factors including ocular biometrics for development of myopia.

Methods : Eighty eyes of 40 patients who received laser treatment with type1 zone2 stage3+ ROP were examined. Fundus examination, retinoscopy, and A-mode ultrasonography were performed at 1-year-old. The correlation between gestational age, birth weight, laser irradiation count, ocular biometrics and equivalent spherical power were studied by multivariate analysis [peason].

Results : The average gestational age of subjects was 26 weeks 4 days±18.9 days, and the average birth weight was 831.1g±392.6g. In our hospital, all PCs were performed in both eyes in a single operation, and the average irradiation number was 1223.8±359.3 for one eye. Ocular axial length was 19.7±1.5mm (16.26mm to 27.33mm), lens thickness was 3.9±0.5mm and anterior chamber depth was 2.92±0.5mm (average±SD). Spherical aberration was +0.21D±3.05D (-10.0D to +6.0D). Sixteen eyes (20%) had myopic eyes of -2.0D or more. The ocular axial length (R=-0.24, p=0.003067) and the laser irradiation count (R=-0.51, p=0.00088) were correlated significantly with the equivalent spherical power. Furthermore, the significant positive correlation was found between ocular axial length and laser irradiation count (R=0.45 p=0.00342).

Conclusions : This study suggested that elongation of ocular axial length at 1 year of age by laser treatment of ROP might cause a myopia from an early stage of life.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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