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Motohiro Itoi, Tsutomu Inatomi, Chie Sotozono; The characteristics of acute corneal hydrops in keratoconus with atopic dermatitis. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3775. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate and compare the character of acute corneal hydrops (ACH) in keratoconus between with and without atopic dermatitis in Japan patients.
In this retrospective study, we reviewed all patients with keratoconus and ACH seen at the Kyoto Prefectural University of Medicine, Kyoto, Japan between January 2013 and December 2016. Patients were divided into a study group consisting of patients suffering from atopic dermatitis (23 eyes of 20 patients) and a control group of patients without known atopic syndrome (29 eyes of 30 patients). Patient age at onset of ACH, best corrected visual acuity (BCVA) with rigid contact lens, and the variations between right and left eyes were investigated. We also investigated the previous keratometry values (Ks and Kf) in the patients who visited our hospital before the onset of hydrops: 8 eyes of 8 study-group patients and 9 eyes of 9 control-group patients.patients for study group and 9 eyes of 9 patients for control group.
Mean patient age at the onset of ACH in the study group and the control group was 28.1±8.7 years and 28.1±9.7 years, respectively, with no statistically significant differences found between the two groups. The BCVA post ACH was poorer in the study group (LogMAR: 0.49±0.69) than in the control group (LogMAR: -0.03±0.44). There were 3 cases of bilateral ACH and 17 cases of unilateral ACH in the study group (6 right eyes and 11 left eyes), and 2 cases of bilateral ACH and 26 cases of unilateral ACH in the control group (10 right eyes and 16 left eyes). No statistically significant difference in the variation of right and left eyes was found between the two groups. There were no statistically significant differences in Ks and Kf at before hydrops between study group (49.7±6.7 and 61.1±10.7), respectively) and the control group (46.5±5.4 and 56.9±5.8, respectively).
Atopic dermatitis may lead to exacerbation of the prognosis of ACH, despite the trend of no difference in the onset age, previous keratometry values and the variations of right and left eyes. The evaluation for the severity of keratoconus via multiple examinations associate with the pathogenesis of atopic dermatitis at before and after the onset of hydrops was required to reveal the mechanism of worsening the prognosis of ACH with Atopic dermatitis.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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