July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Ten-year follow-up of eyes with waterclefts in Monzen Eye Study
Author Affiliations & Notes
  • Eri Shibuya
    Department of Ophthalmology, Kanazawa Medical University, Kahoku, ISHIKAWA, Japan
  • Mai Kita
    Department of Ophthalmology, Kanazawa Medical University, Kahoku, ISHIKAWA, Japan
  • Teppei Shibata
    Department of Ophthalmology, Kanazawa Medical University, Kahoku, ISHIKAWA, Japan
  • Hisanori Miyashita
    Department of Ophthalmology, Kanazawa Medical University, Kahoku, ISHIKAWA, Japan
  • Naoki Tanimura
    Department of Ophthalmology, Kanazawa Medical University, Kahoku, ISHIKAWA, Japan
  • Natsuko Hatsusaka
    Department of Ophthalmology, Kanazawa Medical University, Kahoku, ISHIKAWA, Japan
  • Norihiro Mita
    Department of Ophthalmology, Kanazawa Medical University, Kahoku, ISHIKAWA, Japan
  • Eri Kubo
    Department of Ophthalmology, Kanazawa Medical University, Kahoku, ISHIKAWA, Japan
  • Hiroshi Sasaki
    Department of Ophthalmology, Kanazawa Medical University, Kahoku, ISHIKAWA, Japan
  • Footnotes
    Commercial Relationships   Eri Shibuya, None; Mai Kita, None; Teppei Shibata, None; Hisanori Miyashita, None; Naoki Tanimura, None; Natsuko Hatsusaka, None; Norihiro Mita, None; Eri Kubo, None; Hiroshi Sasaki, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3796. doi:https://doi.org/
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      Eri Shibuya, Mai Kita, Teppei Shibata, Hisanori Miyashita, Naoki Tanimura, Natsuko Hatsusaka, Norihiro Mita, Eri Kubo, Hiroshi Sasaki; Ten-year follow-up of eyes with waterclefts in Monzen Eye Study. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3796. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We examined crystalline lens change in Japanese eyes with waterclefts (WC) in a 10-year longitudinal epidemiological study.

Methods : Of 225 participants at both baseline and 10-year follow-up examinations in Monzen Eye Study, 435 eyes of 221 subjects (158 eyes of 81 males, 277 eyes of 140 females, 66.9±6.1 years old at baseline) were enrolled, excluding those implanted with an intraocular lens (IOL) at baseline. Lens opacities were examined by one ophthalmologist under maximum mydriasis, and were classified into 5 types; cortical (COR), nuclear (NUC) or posterior subcapsular cataract (PSC) according to WHO classification, and retrodots (RD) and waterclefts (WC) according to KMU classification systems. Presence of COR inside a 3-mm diameter central pupillary area was classified as CEN+ and outside as CEN-. Likewise, presence of WC was classified as central (WC+) and peripheral (WC-).

Results : Eyes with IOL at the 10-year follow-up comprised 10.4%, 11.1%, 35.6%, and 41.9% of the eyes at baseline with transparent, only WC-, opacities other than WC, and WC- plus other opacities, respectively. Eyes with WC+ at baseline showed significantly higher operation rates; 60.0% in only WC+, 67.7% in WC+ plus other opacities (p<0.001, χ2 test). In eyes without WC at baseline, the 10-year incidence rate of COR was 27.3%, whereas it was a markedly high 45.3% among those with (p=0.15). In eyes with WC at baseline, females showed higher rates of COR progression (47.8%) and CEN+ (19.6%) at the 10-year follow-up, compared to males (26.7% and 6.7%, respectively), but not significantly.

Conclusions : Eyes with WC+ show increased incidence of COR over a 10-year natural course with almost two-thirds requiring surgery.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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