July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Therapeutic Efficacy of Topical Adiponectin-Derived Short Peptides and Globular Adiponectin after alkali burn
Author Affiliations & Notes
  • Ying Li
    Department of ophthalmology, Chonnam National University Medical School & Hosp., Gwangju, Korea (the Democratic People's Republic of)
  • Ru Jun Jin
    Department of ophthalmology, Chonnam National University Medical School & Hosp., Gwangju, Korea (the Democratic People's Republic of)
  • Jung-Han Choi
    Department of ophthalmology, Chonnam National University Medical School & Hosp., Gwangju, Korea (the Democratic People's Republic of)
  • Henry Hsu
    Allysta Pharmaceuticals, Belmont, Virgin Islands (U.S.)
  • Laszlo Otvos
    Olpe LLC, Audubon, Virgin Islands (U.S.)
  • Eva Surmacz
    Temple University, Philadelphia, Virgin Islands (U.S.)
  • Kyung Chul Yoon
    Department of ophthalmology, Chonnam National University Medical School & Hosp., Gwangju, Korea (the Democratic People's Republic of)
  • Footnotes
    Commercial Relationships   Ying Li, None; Ru Jin, None; Jung-Han Choi, None; Henry Hsu, None; Laszlo Otvos, None; Eva Surmacz, None; Kyung Chul Yoon, None
  • Footnotes
    Support  This study was partially supported by the Hanmi Pharmaceutical Co., Ltd. and Chonnam National University Hospital Biomedical Research Institute (CRI 13906-22).
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3838. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ying Li, Ru Jun Jin, Jung-Han Choi, Henry Hsu, Laszlo Otvos, Eva Surmacz, Kyung Chul Yoon; Therapeutic Efficacy of Topical Adiponectin-Derived Short Peptides and Globular Adiponectin after alkali burn. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3838.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To evaluate the efficacy of topical adiponectin (APN)-derived short peptides compared with the globular adiponectin after corneal alkali burn.

Methods : Chemical burn was induced using 0.1 M NaOH in both adenovirus 12-SV40 hybrid-transformed C57BL/6 mice. Eye drops containing 0.01% globular APN, 0.01% or 0.1% APN-derived peptide (ADP) 355, or balanced salt solution (BSS) were applied. Corneal epithelial defects and degree of haze were analyzed 6 h and 1, 2, 3, 6, and 7 days after chemical injury. The concentrations of IL-1β and transforming growth factor-β (TGF-β) in the cornea were measured using enzyme-linked immunosorbent assay after 7 days injury.

Results : The globular APN and both ADP 355 groups showed a significant improvement in epithelial defect parameters and haze scores at 3, 5, and 7 days after chemical injury. A significant decreased in IL-1β and TGF-β levels were observed in all of APN treatment groups. However, there were no significant differences in all clinical and experimental parameters among the globular APN and both ADP 355 groups.

Conclusions : Topical application of ANP-derived peptides could increase epithelial, improve clinical signs and decrease inflammation of the ocular surface after alkali burn, and the effects were similar to those of globular ADP.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×