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Ying Li, Ru Jun Jin, Jung-Han Choi, Henry Hsu, Laszlo Otvos, Eva Surmacz, Kyung Chul Yoon; Therapeutic Efficacy of Topical Adiponectin-Derived Short Peptides and Globular Adiponectin after alkali burn. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3838.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the efficacy of topical adiponectin (APN)-derived short peptides compared with the globular adiponectin after corneal alkali burn.
Chemical burn was induced using 0.1 M NaOH in both adenovirus 12-SV40 hybrid-transformed C57BL/6 mice. Eye drops containing 0.01% globular APN, 0.01% or 0.1% APN-derived peptide (ADP) 355, or balanced salt solution (BSS) were applied. Corneal epithelial defects and degree of haze were analyzed 6 h and 1, 2, 3, 6, and 7 days after chemical injury. The concentrations of IL-1β and transforming growth factor-β (TGF-β) in the cornea were measured using enzyme-linked immunosorbent assay after 7 days injury.
The globular APN and both ADP 355 groups showed a significant improvement in epithelial defect parameters and haze scores at 3, 5, and 7 days after chemical injury. A significant decreased in IL-1β and TGF-β levels were observed in all of APN treatment groups. However, there were no significant differences in all clinical and experimental parameters among the globular APN and both ADP 355 groups.
Topical application of ANP-derived peptides could increase epithelial, improve clinical signs and decrease inflammation of the ocular surface after alkali burn, and the effects were similar to those of globular ADP.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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