July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
OPTIC NERVE HEAD MORPHOLOGY IN PREMATURE INFANTS 30-42 WEEKS POST MENSTRUAL AGE BY RETINOPATHY OF PREMATURITY STATUS USING HAND-HELD ULTRA-HIGH RESOLUTION SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY
Author Affiliations & Notes
  • Aarti Patel
    Ophthalmology Group, University of Leicester, Leicester, ENGLAND, United Kingdom
  • Brad Manktelow
    University of Leicester, Department of Health Sciences, Leicester, United Kingdom
  • Joe Fawke
    University Hospitals of Leicester, Neonatology Department, Leicester, United Kingdom
  • Frank A Proudlock
    Ophthalmology Group, University of Leicester, Leicester, ENGLAND, United Kingdom
  • Irene Gottlob
    Ophthalmology Group, University of Leicester, Leicester, ENGLAND, United Kingdom
  • Footnotes
    Commercial Relationships   Aarti Patel, None; Brad Manktelow, None; Joe Fawke, None; Frank Proudlock, None; Irene Gottlob, None
  • Footnotes
    Support  DRF-2014-07-136, MR/N004566/1, MR/J004189/1
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3934. doi:https://doi.org/
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      Aarti Patel, Brad Manktelow, Joe Fawke, Frank A Proudlock, Irene Gottlob; OPTIC NERVE HEAD MORPHOLOGY IN PREMATURE INFANTS 30-42 WEEKS POST MENSTRUAL AGE BY RETINOPATHY OF PREMATURITY STATUS USING HAND-HELD ULTRA-HIGH RESOLUTION SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3934. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Retinopathy of prematurity (ROP) is an important cause of preventable blindness necessitating multiple examinations during early development. Ultra-high resolution spectral domain hand-held OCT (HHOCT) provides detailed imaging of important retinal structures in premature infants and may be a useful additional screening tool. We describe the optic nerve head (ONH) development for premature infants aged between 30-42 weeks postmenstrual age (PMA) screened for ROP.

Methods : 121 premature infants (≤32 weeks gestational age at birth or ≤1500g birth weight) were recruited to the study. Early prognostic changes in the ONH were evaluated by grouping infants according to the final ROP outcome; none (group 1), regressed without treatment (group 2), or treated with laser (group 3). Ophthalmic examination and HHOCT scan (Leica Microsystems, 2.6µm axial resolution) were performed between 30-42 weeks PMA without sedation. ONH images were analysed using a customised macro in ImageJ. Diametric parameters were quantified and peri-papillary parameters were calculated at 6° from the disc centre. Developmental trajectories were compared between groups using fractional polynomial modelling.

Results : All optic nerve head parameters were statistically similar for the two least severe ROP groups between 30-42 weeks PMA (group 2 compared to group 1: p>0.05). Infants requiring laser demonstrated a smaller disc diameter compared to infants without ROP throughout early development (group 3 compared to group 1: p<0.05). At 32 weeks PMA the cup diameter was 32% smaller in group 3 compared to group 1 infants (p=0.005), increasing to a statistically similar size by 40 weeks PMA. The nasal and temporal basement membrane opening minimum rim width (BMO-MRW) were initially 24% and 22% greater, respectively, in group 3 compared to group 1 infants (p<0.05), and also reached statistical equivalence by 40 weeks PMA.

Conclusions : We report the developmental trajectory of ONH parameters for premature infants 30-42 weeks PMA for the first time using HHOCT. Our results demonstrate smaller optic disc and cup diameter and greater BMO-MRW at 32 weeks PMA for infants who develop ROP requiring laser treatment compared to infants who do not develop any ROP. These results may be useful for risk-stratifying patients for ROP screening.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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