July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
MRI imaging of eye shape and associations with myopia in Singapore adults
Author Affiliations & Notes
  • Saiko Matsumura
    Singapore Eye Research Institute, Singapore, Singapore
  • Laurence Shen Lim
    Singapore National Eye Centre, Singapore, Singapore
  • Hla Myint Htoon
    Singapore Eye Research Institute, Singapore, Singapore
  • Shinbin Lim
    Singapore National Eye Centre, Singapore, Singapore
  • James Tian
    Ophthalmology, Duke University, Durham, North Carolina, United States
  • Sonoko Sensaki
    Neonatology, National University Hospital, Singapore, Singapore
  • Christopher Li-Hsian Chen
    National University of Singapore, Singapore, Singapore
  • Saima Hilal
    National University of Singapore, Singapore, Singapore
  • Tien Yin Wong
    Singapore Eye Research Institute, Singapore, Singapore
    Singapore National Eye Centre, Singapore, Singapore
  • Ching-Yu Cheng
    Singapore Eye Research Institute, Singapore, Singapore
    Singapore National Eye Centre, Singapore, Singapore
  • Anthony N Kuo
    Ophthalmology, Duke University, Durham, North Carolina, United States
  • Seang-Mei Saw
    Singapore Eye Research Institute, Singapore, Singapore
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Saiko Matsumura, None; Laurence Lim, None; Hla Htoon, None; Shinbin Lim, None; James Tian, None; Sonoko Sensaki, None; Christopher Chen, None; Saima Hilal, None; Tien Yin Wong, None; Ching-Yu Cheng, None; Anthony Kuo, None; Seang-Mei Saw, None
  • Footnotes
    Support  National Medical Research Council -- NMRC/0975/2005
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3955. doi:
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      Saiko Matsumura, Laurence Shen Lim, Hla Myint Htoon, Shinbin Lim, James Tian, Sonoko Sensaki, Christopher Li-Hsian Chen, Saima Hilal, Tien Yin Wong, Ching-Yu Cheng, Anthony N Kuo, Seang-Mei Saw; MRI imaging of eye shape and associations with myopia in Singapore adults. Invest. Ophthalmol. Vis. Sci. 2018;59(9):3955.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare eye shape across the refractive error range using brain magnetic resonance imaging (MRI) images in Singapore adults.

Methods : A total of 450 participants aged 50 years and above (64.2 +/- 6.5 years old) in the Singapore Epidemiology of Eye Disease (SEED) study (169 Chinese, 165 Indians and 116 Malays) were included. Refraction was performed using an autorefractor, and axial length (AL) was measured using optical biometry (IOLMaster, Zeiss). The MRI volumes (3T Magnetom Trio Tim; Siemens) of the right eye were semi-automatically segmented in the axial planes, and posterior eye radius of curvature (Rc) (related to total eye volume) and asphericity (Qxz with > 0 as oblate, < 0 as prolate) were calculated. Multivariate liner regression models were used to identify Rc and Qxz and associations with spherical equivalent (SE) and AL, controlling for confounders.

Results : Among 441 eligible subjects, the prevalence of myopia (-0.50 Diopter (D) > SE) and high myopia (-5.00D > SE) were 25.6% and 3.6%, respectively. Rc was correlated positively with AL (Pearson correlation coefficient, r = 0.56) and negatively with SE (r = -0.27). Qxz was correlated negatively with AL (r=-0.50) and positively with SE (r=0.44). Both larger eye volume and prolate eye shape were correlated with longer AL and worse SE. Multivariable regression analysis revealed that larger eye volume, (larger Rc) was associated with worse SE (B = -1.8, 95% confidence interval (CI) -2.3 to -1.3, p < 0.001)), longer AL (B =1.4, CI 1.2 to 1.6, p < 0.001) and myopia (odds ratio (OR) = 4.3, CI 2.6 to 7.42, p < 0.001). Lower Qxz indicating increasing axial prolateness was also associated with worse SE (B = 6.6, CI 5.6 to 7.9, p < 0.001), longer AL (B= -3.5, CI -4.0 to -3.0, p < 0.001) and myopia (p<0.001). Comparison among 3 groups with different SE: Non-myopia (SE > -0.50 D), mild-moderate myopia (-0.50 D > SE > -5.00 D) and high myopia (SE < -5.00 D) showed only 10% of mild-moderate myopic eyes were prolate, >50% of high myopic eyes were prolate.

Conclusions : We have demonstrated that eye volume and the prolate eye shape were associated with myopic eyes, and that the prolate changes of myopic eyes become more prominent in the group with high myopia. Clinically, our findings are important because eye shape may be an important imaging biomarker for high myopia and pathologic myopia changes.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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