July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Structure-function relationship in the aging process in normal subjects
Author Affiliations & Notes
  • Makoto Araie
    Ophthalmology, Kanto Central Hospital, Mutual Aid Association of Public School Teachers, Setagaya-Ku, TOKYO, Japan
  • Makoto Fujii
    Tajimi Iwase Eye Clinic, Tajimi, Japan
  • Yuko Ohno
    Tajimi Iwase Eye Clinic, Tajimi, Japan
  • Yuki Tanaka
    Santen Pharmaceutical, Tokyo, Japan
  • Tsutomu Kikawa
    Topcon Corporation, Tokyo, Japan
  • Aiko Iwase
    Tajimi Iwase Eye Clinic, Tajimi, Japan
  • Footnotes
    Commercial Relationships   Makoto Araie, Aerie (C), Alcon (F), Heidelberg Engineering (C), Heidelberg Engineering (F), Kowa (C), Kowa (F), Otsuka (F), Pfizer (C), Santen (C), Santen (F), Senju (C), Senju (F), Topcon medical System (C), Topcon medical System (F), Topcon medical System (P); Makoto Fujii, None; Yuko Ohno, None; Yuki Tanaka, Santen (E); Tsutomu Kikawa, Topcon (E); Aiko Iwase, Alcon (F), Carl Zeiss Meditec (F), Heidelberg Engineering (F), Kowa (F), Pfizer (F), Santen (F), Senju (F), Topcon (F), Topcon (P), Topcon medical System (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4054. doi:
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    • Get Citation

      Makoto Araie, Makoto Fujii, Yuko Ohno, Yuki Tanaka, Tsutomu Kikawa, Aiko Iwase; Structure-function relationship in the aging process in normal subjects. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4054.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Previous studies indicated that changes in the spectral-domain optical coherence tomography (SD-OCT)-measured thicknesses of retinal ganglion cell (RGC)-related retinal layers, i.e., structure, generally preceded those in the standard automated perimetry (SAP)-measured sensitivity, i.e., function, in the early stage of glaucoma. Though cross-sectional studies showed that both the structure and function declined along with aging in normal eyes, there is a paucity of information on the structure-function relationship associated with the aging process. We compared aging changes of SAP sensitivities and SD-OCT-measurement results in the corresponding retinal areas in normal eyes.

Methods : Humphrey Field Analyzer 24-2 SITA-S program tests (HFA-24-2) and parapapillary and macular SD-OCT measurements using OCT-2000 (Topcon, Japan) were done every 3 months for 3 years in 76 eyes of 38 normal subjects aged 51.6 ± 12.8 (SD) years. Change rates of the average sensitivities of the all HFA 24-2 points, that of the central 4 points, circumpapillary retinal nerve fiber layer thickness (CpRNFLT) and ganglion cell-inner plexiform layer thickness (GCIPLT) in 4 regions with 2° of visual angle corresponding to the 4 central points (GCIPLTcentral4) were analyzed using the linear mixed model adjusting for the age, baseline values, axial length (AL) and disc area.

Results : Aging-related change rate in the average sensitivity of the all HFA 24-2 points corresponding to CpRNFLT and that of the 4 central points corresponding to GCIPLTcentral4 adjusted for the above covariates were -0.19 and -0.20 dB/year (P=0.015,<0.001), and -38 and -92 (1/Lambert)/year (P<0.001), respectively, with higher age (P=0.019~0.003) and baseline sensitivity (P=0.017~<0.001) associating with higher change rate. On the other hand, no significant aging-related changes could be detected in CpRNFLT or GCIPLTcentral4, except that higher age associated with a small increase in the decline rate (0.002m/year, P=0.0007) of CpRNFLT.

Conclusions : As far as the current normal subjects were concerned, aging-related change could not be detected in CpRNFLT and GCIPLT central4 in 3 years, while SAP sensitivities in the corresponding retinal regions showed significant decline, suggesting that structure-function relationship in the physiological aging process may be different from that in the early stage-glaucoma.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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