July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Cluster analysis of computerized visual field(VF) and Optical Coherence Tomography-Ganglion Cell Complex(OCT-GCC) defects in high intraocular pressure patients.
Author Affiliations & Notes
  • Andrea Perdicchi
    Azienda ospedaliera Sant'Andrea, Rome, Italy
    NESMOS, Ophthalmology Unit, University of Rome “Sapienza, Rome, Italy
  • Alessandro de Paula
    Azienda ospedaliera Sant'Andrea, Rome, Italy
    NESMOS, Ophthalmology Unit, University of Rome “Sapienza, Rome, Italy
  • Edoardo Sordi
    Azienda ospedaliera Sant'Andrea, Rome, Italy
    NESMOS, Ophthalmology Unit, University of Rome “Sapienza, Rome, Italy
  • Alessandra Rosati
    Azienda ospedaliera Sant'Andrea, Rome, Italy
    NESMOS, Ophthalmology Unit, University of Rome “Sapienza, Rome, Italy
  • Gianluca Scuderi
    Azienda ospedaliera Sant'Andrea, Rome, Italy
    NESMOS, Ophthalmology Unit, University of Rome “Sapienza, Rome, Italy
  • Footnotes
    Commercial Relationships   Andrea Perdicchi, None; Alessandro de Paula, None; Edoardo Sordi, None; Alessandra Rosati, None; Gianluca Scuderi, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4078. doi:
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      Andrea Perdicchi, Alessandro de Paula, Edoardo Sordi, Alessandra Rosati, Gianluca Scuderi; Cluster analysis of computerized visual field(VF) and Optical Coherence Tomography-Ganglion Cell Complex(OCT-GCC) defects in high intraocular pressure patients.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4078.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of the study is to evaluate the relationships between functional defects shown by cluster analysis of computerized visual field (VF) and anatomic defects at Optical Coherence Tomography-Ganglion Cell Complex examination(OCT-GCC) in ocular hypertension or eyes with glaucoma.

Methods : 320 eyes affected by ocular hypertension(IOP>22 mmHg) were enrolled. The age of the patients ranged from 26 to 87 years (average 61.83±1.54 years). Computerized 30° VF(Octopus G1x Dynamic strategy) and OCT-GCC(I-Vue Optovue) analysis were performed for each eye selected. The VF was considered abnormal with a Mean Defect(MD)>2 and Loss Variance(LV)>6. The OCT-GCC was considered abnormal with a Focal Loss Volume(FLV)<5% and/or a thinning of total, superior or inferior thickness(p<5%). 4 different groups of eyes were created according to the results of VF and GCC: normal VF and normal GCC (group 1), abnormal VF and abnormal GCC(group 2), normal VF and abnormal GCC(group 3), abnormal VF and normal GCC(group 4). The cluster analysis of VFs(EyeSuite software Interzeag CH) was done only in the eyes of group 3, considering the correlation of these two exams with and without the topographical correspondence between them.

Results : GCC and VF exams matched in 247(77.19%) of all the eyes examined. 143 eyes belonged to group 1 and 104 eyes belonged to group 2, 23 eyes belonged to group 3 and 50 eyes belonged to group 4. The cluster analysis performed on group 3 showed that the correspondence between OCT-GCC and cluster analysis of visual field defects was 100%(both the exams altered). In 72% of them there was a topographical correspondence between the visual field and OCT-GCC defect.

Conclusions : In early stage glaucoma the analysis of visual field by clusters is useful to detect some focal defects that can be hidden by a global evaluation of the exam. In fact in this study the cluster analysis on group 3, where the VF was normal and the OCT-GCC abnormal, showed a topographical correlation between the visual field and OCT-GCC defects in more than 70% of the eyes examined.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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