Abstract
Purpose :
To investigate the topographic relationship between thickness and vessel density in the macular ganglion cell-inner plexiform layer (mGCIPL) of glaucoma patients.
Methods :
A total of 150 eyes of 150 patients with early-stage glaucoma (visual field [VF] mean deviation between -1.5 and -5.5 decibels [dB]) were imaged using the optical coherence tomography (OCT) and OCT angiography (OCTA). The mGCIPL thickness and retinal nerve fiber layer (RNFL) thickness was measured by Cirrus HD-OCT and the vessel density of mGCIPL was measured by OCTA.
Results :
The mGCIPL thickness of superior segment and inferior segment showed strong correlation with superficial vessel density of superior segment and inferior segment, respectively (P < 0.001 for both segments). In inferior segment, inferior vessel density had stronger correlation with inferotemporal RNFL thickness than inferior mGCIPL thickness (P = 0.008).
Conclusions :
Sectorial macular superficial vessel density had strong correlation with mGCIPL thickness in glaucoma patients. In inferior sector, macular superficial vessel density had stronger correlation with corresponding RNFL thickness than with mGCIPL thickness. Macular superficial vessel density analysis can be a complementary tool to detect early glaucoma.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.