July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Topographic correlation between thickness and vessel density in the macular ganglion cell-inner plexiform layer of glaucoma patients
Author Affiliations & Notes
  • Jin-Soo Kim
    Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • SungUk Baek
    Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
    Ophthalmology, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Young Kook Kim
    Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
    Ophthalmology, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Jin Wook Jeoung
    Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
    Ophthalmology, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Ki Ho Park
    Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
    Ophthalmology, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4086. doi:
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      Jin-Soo Kim, SungUk Baek, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park; Topographic correlation between thickness and vessel density in the macular ganglion cell-inner plexiform layer of glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4086.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the topographic relationship between thickness and vessel density in the macular ganglion cell-inner plexiform layer (mGCIPL) of glaucoma patients.

Methods : A total of 150 eyes of 150 patients with early-stage glaucoma (visual field [VF] mean deviation between -1.5 and -5.5 decibels [dB]) were imaged using the optical coherence tomography (OCT) and OCT angiography (OCTA). The mGCIPL thickness and retinal nerve fiber layer (RNFL) thickness was measured by Cirrus HD-OCT and the vessel density of mGCIPL was measured by OCTA.

Results : The mGCIPL thickness of superior segment and inferior segment showed strong correlation with superficial vessel density of superior segment and inferior segment, respectively (P < 0.001 for both segments). In inferior segment, inferior vessel density had stronger correlation with inferotemporal RNFL thickness than inferior mGCIPL thickness (P = 0.008).

Conclusions : Sectorial macular superficial vessel density had strong correlation with mGCIPL thickness in glaucoma patients. In inferior sector, macular superficial vessel density had stronger correlation with corresponding RNFL thickness than with mGCIPL thickness. Macular superficial vessel density analysis can be a complementary tool to detect early glaucoma.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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