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toshihiko murata, Kei Takayama, Kozo Harimoto, Koji Kanda, Tomohito Sato, Masaru Takeuchi; Evaluation of Subclinical Inflammation in Chronic Vogt-Koyanagi-Harada Disease by Multiple Testing. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4207.
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© ARVO (1962-2015); The Authors (2016-present)
Vogt-Koyanagi-Harada (VKH) disease is an autoimmune Th1 type reaction directed against proteins related to stromal choroidal melanocytes. To investigate ocular inflammation, anterior aqueous flare and choroidal thickness measurement are used to detect the inflammation in the anterior and posterior segments, respectively. Although the inflammatory reaction in VKH is sometimes mild and remains subclinical in choroid, the diagnosis of subclinical progression is difficult without sensitive investigational tests of the choroid, and should be evaluated by multiple testing. The purpose of this study was to compare and detect correlations between the inflammation scores in the anterior and posterior segments including ICGA score, and estimate the usefulness of ICGA score in eyes with chronic VKH disease.
Consecutive clinical records of twenty-four eyes in 12 patients with chronic VHK (6 males, mean age was 54.8 ± 14.9 years) were retrospectively reviewed. Visual acuity, intraocular pressure (IOP), ICGA score, central choroidal thickness (CCT) measured by enhanced depth imaging optical coherence tomography (Spectralis OCT®, Heidelberg, Germany), anterior aqueous flare measured by laser flare photometer (FM-700®, KOWA, Japan), and whole amount of systemic corticosteroid medication were compared. Multiple linear regression analysis was used to detect any correlations between these outcomes.
Mean visual acuity, mean IOP, mean ICGA score, mean CCT and mean aqueous flare were -0.08 ± 0.15, 14.9 ± 2.6 mmHg, 6.0 ± 4.3, 257 ± 99 μm, and 11.8 ± 7.9 pc/ms, respectively. There were no significant differences in all parameters between male and female. Multiple linear regression analysis suspected positive correlations between ICGA score and whole amount of systemic corticosteroid medication（r = 0.70, P < 0.01）and aqueous flare and whole amount of systemic corticosteroid medication （r = 0.49, P < 0.01）. There were no significant correlations among ICGA score, aqueous flare, and CCT.
There would be no significant correlations between anterior and posterior inflammations in eyes with chronic VKH. ICGA score might be necessary independently to evaluate subclinical ocular inflammation of chronic VKH.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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